人免疫球蛋白轻链的等位基因抗原因子Inv(a)：化学基础。
Allelic antigenic factor Inv(a) of the light chains of human immunoglobulins: chemical basis.
作者信息
Baglioni C, Alescio Zonta L, Cioli D, Carbonara A
出版信息
Science. 1966 Jun 10;152(3728):1517-9. doi: 10.1126/science.152.3728.1517.
PMID:5934342
Abstract
Twenty-seven Bence Jones proteins of immunological type K show a common set of peptides. One 6f the commnon peptides differs in three of the proteins which are the only ones classified by a serological test as Iav(a+). The difference in the peptide analyzed is caused by a valine-leucine interchange; Inv(a+) proteins have leucine, whereas Inv(a-) proteins have valine in position 189.
摘要
27种免疫类型为K的本斯·琼斯蛋白显示出一组共同的肽段。其中一种共同肽段在3种蛋白中有所不同，这3种蛋白是仅通过血清学检测归类为Inv(a+)的蛋白。所分析肽段的差异是由缬氨酸 - 亮氨酸互换引起的；Inv(a+)蛋白在第189位有亮氨酸，而Inv(a-)蛋白在该位置有缬氨酸。
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