小鼠免疫球蛋白轻链可变区中的一种遗传标记。
A genetic marker in the variable region of light chains of mouse immunoglobulins.
作者信息
Edelman G M, Gottlieb P D
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9. doi: 10.1073/pnas.67.3.1192.
Abstract
A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.
摘要
在对来自17种不同近交系小鼠的（14）C标记正常轻链的胰蛋白酶肽图进行放射自显影比较时，观察到一种基因变异。在AKR/J、C58/J和RF/J品系中发现了差异。化学分析表明，差异存在于轻链可变区半胱氨酸I附近的氨基酸序列区域。育种实验表明，这种差异以经典孟德尔方式分离。
Zotero 插件