Appella E, Chersi A, Mage R G, Dubiski S
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1341-5. doi: 10.1073/pnas.68.6.1341.
The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cgamma2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cgamma2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human gamma chains is apparent (about 60-80%).
利用从纯合兔制备的Fc片段,研究了兔免疫球蛋白G的A14和A15同种异型特异性的结构基础。Cγ2区域(位置309:按E序号)中苏氨酸的存在与A14同种异型相关;同一位置上丙氨酸的存在与A15相关。既然兔IgG的Cγ2区域序列已完全阐明,那么兔和人γ链恒定区结构域的高度同源性就很明显了(约60 - 80%)。