氯喹：伯氏疟原虫耐药性的生理基础
Chloroquine: physiological basis of drug resistance in Plasmodium berghei.
作者信息
Macomber P B, O'Brien R L, Hahn F E
出版信息
Science. 1966 Jun 3;152(3727):1374-5. doi: 10.1126/science.152.3727.1374.
PMID:5937128
Abstract
Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.
摘要
被氯喹敏感疟原虫寄生的小鼠红细胞在体内将这种药物浓缩至比被氯喹耐药疟原虫寄生的红细胞高出两倍多的水平；未被寄生的红细胞积累的氯喹很少。这种药物的选择性毒性可能取决于疟原虫的一种特殊药物浓缩机制，或者是这种机制的损伤。
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