不同年龄大鼠皮肤的代谢变化。氧气消耗及葡萄糖摄取。
Metabolic changes in the skin of rats of various ages. Oxygen consumption and uptake of glucose.
作者信息
Patnaik B K, Kanungo M S
出版信息
Biochem J. 1966 Feb;98(2):374-7. doi: 10.1042/bj0980374.
Abstract
- Parallel determinations of the oxygen consumption by skin slices with glucose or galactose as substrate and of the concentration of DNA of the skin of various ages of rats were carried out to study the metabolic changes of the skin with age. 2. Both the oxygen consumption and the DNA content of the skin decreased rapidly till the attainment of maturity; thereafter the rate of decrease in oxygen consumption was lower whereas the concentration of DNA was constant. The decrease in the oxygen consumption during the early developmental period is thus due to the loss of cells, but the decrease in the older rats may be due to a decline in the activity of the cells of the skin as a result of aging. 3. The uptake of glucose by the skin decreased with increasing age.
摘要
- 为了研究皮肤随年龄的代谢变化，对以葡萄糖或半乳糖为底物的皮肤切片耗氧量以及不同年龄大鼠皮肤的DNA浓度进行了平行测定。2. 皮肤的耗氧量和DNA含量在成熟前迅速下降；此后，耗氧量的下降速率较低，而DNA浓度保持恒定。因此，发育早期耗氧量的下降是由于细胞丢失，但老年大鼠耗氧量的下降可能是由于衰老导致皮肤细胞活性下降。3. 皮肤对葡萄糖的摄取随年龄增长而减少。
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