抗坏血酸与大鼠衰老。牙齿对抗坏血酸的摄取以及不同器官中各种形式抗坏血酸的浓度。
Ascorbic acid and aging in the rat. Uptake of ascorbic acid by teeth and concentration of various forms of ascorbic acid in different organs.
作者信息
Patnaik B K, Kanungo M S
出版信息
Biochem J. 1966 Jul;100(1):59-62. doi: 10.1042/bj1000059.
Abstract
- The uptake of ascorbic acid in vitro by the teeth of rats showed a gradual decrease with age, indicating that the uptake may be related to collagen synthesis as in bone. 2. The concentration of total free ascorbic acid in various organs declined with age, but the rate of decline was different in different organs. In the spleen, however, it increased until maturity and then declined. 3. This decrease may be due to one or both of the following reasons: (a) the permeability of different tissues may decrease at different rates for ascorbic acid, or (b) the requirement for ascorbic acid may decrease at different rates. 4. The bound ascorbic acid declined with age in the skin, kidney, liver and brain after the age of 10-12 weeks, and in the spleen after the age of 26 weeks. 5. The concentration of dehydroascorbic acid and dioxogulonic acid declined with age in the skin.
摘要
- 大鼠牙齿在体外对抗坏血酸的摄取量随年龄增长逐渐减少，这表明这种摄取可能与骨骼中一样，与胶原蛋白合成有关。2. 各器官中总游离抗坏血酸的浓度随年龄下降，但不同器官的下降速率不同。然而，在脾脏中，它在成熟前增加，然后下降。3. 这种下降可能归因于以下一个或两个原因：(a) 不同组织对抗坏血酸的通透性可能以不同速率降低，或者 (b) 对抗坏血酸的需求可能以不同速率降低。4. 10 - 12周龄后，皮肤、肾脏、肝脏和大脑中的结合抗坏血酸随年龄下降，26周龄后脾脏中的结合抗坏血酸也随年龄下降。5. 皮肤中脱氢抗坏血酸和二氧古洛糖酸的浓度随年龄下降。
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Gerontologia. 1964;10:155-60. doi: 10.1159/000211402.
2
ENZYMATIC HYDROXYLATION OF PROLINE IN MICROSOMAL POLYPEPTIDE LEADING TO FORMATION OF COLLAGEN.微粒体多肽中脯氨酸的酶促羟基化作用导致胶原蛋白的形成。
Proc Natl Acad Sci U S A. 1965 Feb;53(2):335-42. doi: 10.1073/pnas.53.2.335.
3
BIOSYNTHESIS OF L-ASCORBIC ACID IN RAT LIVER MICROSOMES: INFLUENCES OF AGE, SEX, DIETARY CHANGES, AND WHOLE-BODY X-IRRADIATION.大鼠肝脏微粒体中L-抗坏血酸的生物合成：年龄、性别、饮食变化及全身X射线照射的影响
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Studies on the distribution of L-ascorbic acid in the rat.大鼠体内L-抗坏血酸分布的研究。
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