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大鼠小肠体外对醋酸甘油酯的处理

Handling of glycerides of acetic acid by rat small intestine in vitro.

作者信息

Barry R J, Jackson M J, Smyth D H

出版信息

J Physiol. 1966 Aug;185(3):667-83. doi: 10.1113/jphysiol.1966.sp008009.

Abstract
  1. When mono-, di- and triacetins are incubated with sacs of rat everted intestine, they enter the epithelial cells and are hydrolysed to free glycerol and acetic acid.2. The rate-limiting step in the process is the entry of glyceride into the epithelial cell.3. The three acetins enter the epithelial cell at the same rate, and the mechanism of this remains unknown.4. The acetate released appears in higher concentrations on the serosal side, and the relation of this to the mechanism for transfer of volatile fatty acids is discussed.5. It is not necessary to postulate a special mechanism for entry of volatile fatty acids into the cell.
摘要
  1. 当单乙酸甘油酯、二乙酸甘油酯和三乙酸甘油酯与大鼠外翻肠囊一起温育时,它们进入上皮细胞并被水解为游离甘油和乙酸。

  2. 该过程中的限速步骤是甘油酯进入上皮细胞。

  3. 三种乙酸甘油酯以相同的速率进入上皮细胞,其机制尚不清楚。

  4. 释放出的乙酸在浆膜侧以更高的浓度出现,并讨论了其与挥发性脂肪酸转运机制的关系。

  5. 没有必要假定挥发性脂肪酸进入细胞存在特殊机制。

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Monoacylglycerol metabolism in rat small intestinal epithelial cells.
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Demonstration of glyceride synthesis by brush borders of intestinal epithelial cells.
Biochem Biophys Res Commun. 1965 Oct 8;21(1):83-8. doi: 10.1016/0006-291x(65)90430-4.
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Transfer of propionate by rat small intestine in vitro.大鼠小肠在体外对丙酸盐的转运
J Physiol. 1966 Jan;182(1):150-63. doi: 10.1113/jphysiol.1966.sp007815.
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Inhibition of intestinal protein synthesis and lipid transport by ethionine.
Biochim Biophys Acta. 1966 Aug 3;125(1):166-73. doi: 10.1016/0005-2760(66)90154-8.

本文引用的文献

2
Permeability of luminal surface of intestinal mucosal cells.肠黏膜细胞腔面的通透性。
J Gen Physiol. 1962 Mar;45(4):801-10. doi: 10.1085/jgp.45.4.801.
4
MEMBRANE (CONTACT) DIGESTION.膜(接触)消化
Physiol Rev. 1965 Jul;45:555-95. doi: 10.1152/physrev.1965.45.3.555.
5
FATTY ACID METABOLISM IN SEGMENTS OF RAT INTESTINE.大鼠肠道各段的脂肪酸代谢
Am J Physiol. 1965 Apr;208:607-14. doi: 10.1152/ajplegacy.1965.208.4.607.
8
SPECIFICITIES OF LIPASES.脂肪酶的特异性
J Lipid Res. 1963 Oct;4:369-84.

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