Dobretsov G E, Petrov V A, Borshchevskaia T A, Deev A I, Vladimirov Iu A
Vopr Med Khim. 1977 Nov-Dec(6):818-22.
Peroxidation of lipids caused rearrangements in physical structure of biomembranes as it was shown by a method of fluorescent probes. These structural rearrangements were accompanied by an increase in the viscosity on the surface and in the depth of the phospholipid bilayer. The increase in the viscosity was apparently due to oxidation and to elimination from the phospholipid bilayer of the unsaturated fatty acid residues. Presence of the unsaturated fatty acids in biomembranes decreases their viscosity. The fraction of saturated fatty acids after peroxidation was respectively increased in the bilayer.
脂质过氧化导致生物膜物理结构重排，荧光探针法已证实此现象。这些结构重排伴随着磷脂双分子层表面及内部粘度增加。粘度增加显然是由于氧化以及不饱和脂肪酸残基从磷脂双分子层中被去除。生物膜中不饱和脂肪酸的存在会降低其粘度。过氧化后双层中饱和脂肪酸的比例相应增加。
