Markiewicz K, Lukin M
Z Gesamte Inn Med. 1977 Nov 1;32(21):563-6.
The purpose of the investigations was the determination of the maximum gastric secretion during hyperglycaemia in healthy subjects as well as in patients with short-term and long-term diabetes. After the stimulation with pentagastrine, given in the dose of 6 microgram per kg of body weight in 0.9% sodium chloride solution continuous intravenous infusion, there were determined MAO, parietal and nonparietal secretions, the concentrations of sodium, potassium, chloride, calcium and magnesium, and the total secretin of these electrolytes in gastric juice. In healthy subjects hyperglycaemia was induced by intravenous infusion of 30% glucose solution. Under the influence of hyperglycaemia the decrease of MAO (p less than 0.001) in healthy subjects as well as in diabetics was found. In healthy subjects the decrease of the total potassium, chloride and magnesium secretion in gastric juice (p less than 0.001) was observed. In patients with long-term diabetes the decrease of the secretion of sodium, potassium, chloride, magnesium and calcium was observed. There were no differences in gastric secretion in both groups of diabetics. The inhibitory effect of hyperglycaemia on the parasympathetic system and the decreased release of endogenous gastrine may be the causes of these changes. Insulin may also inhibit gastric secretion.
这些研究的目的是测定健康受试者以及短期和长期糖尿病患者在高血糖期间的最大胃酸分泌量。在以每千克体重6微克的剂量将五肽胃泌素溶于0.9%氯化钠溶液中持续静脉输注进行刺激后，测定了最大胃酸排出量（MAO）、壁细胞和非壁细胞分泌量、胃液中钠、钾、氯、钙和镁的浓度以及这些电解质的总分泌量。在健康受试者中，通过静脉输注30%葡萄糖溶液诱导高血糖。发现在高血糖的影响下，健康受试者以及糖尿病患者的MAO均降低（p<0.001）。在健康受试者中，观察到胃液中总钾、氯和镁分泌量减少（p<0.001）。在长期糖尿病患者中，观察到钠、钾、氯、镁和钙的分泌量减少。两组糖尿病患者的胃酸分泌没有差异。高血糖对副交感神经系统的抑制作用以及内源性胃泌素释放减少可能是这些变化的原因。胰岛素也可能抑制胃酸分泌。
