Lange C E, Müller N
Z Hautkr. 1977 Nov 15;52(22):1153-9.
In 21 patients with the clinical suspicion of oligosymptomatic R.S.), 21 patients with the clinical suspicion of oligosymptomatic R.S. and 16 patients with recurrent non-gonococcal urethritis 23 HLA-antigens were assessed using a lymphocyte toxicity test. 413 blood donors served as a controll group. 85,7% of the patients with R.S. had phenotyp HLA-B 27 compared with 7,4% of the controll persons. The group with the suspicion of R.S. exhibited with 57,1% a marked increased incidense of HLA-B 27 as well. Compared to this, the HLA-B 27 frequency in the patients with recurrent non-gonococcal urethritis was with 6,3% in especially of its oligosymptomatic courses. Because of the close association between HLA-B 27 and R.S. determination of histocompatibility antigens proved to be a valuable tool in the diagnosis of Reiter's disease, especially of its oligosymptomatic courses.
对21例临床疑似轻症赖特综合征（R.S.）患者、21例临床疑似轻症R.S.患者以及16例复发性非淋菌性尿道炎患者，采用淋巴细胞毒性试验评估23种HLA抗原。413名献血者作为对照组。85.7%的R.S.患者HLA - B27表型阳性，而对照组这一比例为7.4%。疑似R.S.组HLA - B27发生率也显著升高，为57.1%。相比之下，复发性非淋菌性尿道炎患者中HLA - B27频率为6.3%，尤其是在其轻症病程中。由于HLA - B27与R.S.密切相关，组织相容性抗原的测定被证明是诊断赖特病的一项有价值的工具，尤其是对于其轻症病程。
