Hardy M A, Goldfarb P, Levine S, Dattner A, Muggia F M, Levitt S, Weinstein E
Cancer. 1976 Jul;38(1):144-8. doi: 10.1002/1097-0142(197607)38:1<144::aid-cncr2820380123>3.0.co;2-7.
This report describes a de novo development of Kaposi's sarcoma in a Puerto-Rician man 9 months after a cadaveric renal transplant. Progression of the disease was observed despite local irradiation, while the patient remained immunosuppressed with prednisone and azathioprine. This was accompanied by depressed immunologic tests. Discontinuation of azathioprine and addition of chemotherapy (bleomycin and vincristine), while continuing prednisone to maintain functional survival of renal allograft, has led in this patient to regression of extensive cutaneous and suspected pulmonary Kaposi's sarcoma lesions. The possible importance of a depressed immunosurveillance mechanism and activation of latent oncogenic virus by the presence of an allograft in the de novo appearance of Kaposi's sarcoma in transplant recipients is briefly discussed.
本报告描述了一名波多黎各男子在接受尸体肾移植9个月后新发卡波西肉瘤的情况。尽管进行了局部放疗，但疾病仍有进展，而患者继续使用泼尼松和硫唑嘌呤进行免疫抑制治疗。同时伴有免疫检测结果低下。停用硫唑嘌呤并加用化疗药物（博来霉素和长春新碱），同时继续使用泼尼松以维持肾移植的功能存活，使得该患者广泛的皮肤卡波西肉瘤病变及疑似肺部病变出现消退。文中简要讨论了免疫监视机制低下以及移植受体中同种异体移植的存在激活潜在致癌病毒在卡波西肉瘤新发过程中的可能重要性。
