Phillips S D, Salway J G, Payne R B, Macdonald H N
Clin Chim Acta. 1978 Oct 2;89(1):71-8. doi: 10.1016/0009-8981(78)90362-5.
In pregnancies with a normal outcome the oestrogen:creatinine ratio in early morning samples of urine showed a smaller day-to-day variation than the ratio in 24-h urine or the 24-h total oestrogen excretion, and a significant fall could be detected more easily. Patients admitted to hospital who eventually delivered a healthy baby provided a reference range which, after logarithmic transformation, increased linearly with period of gestation. A fall in log10 oestrogen:creatinine ratio exceeding 40% of this range is unusual in pregnancies with a healthy outcome, and suggest impaired fetoplacental function.
在妊娠结局正常的孕妇中，清晨尿样中的雌激素与肌酐比值的每日变化小于24小时尿样中的比值或24小时雌激素总排泄量，且更容易检测到显著下降。最终分娩出健康婴儿的住院患者提供了一个参考范围，经对数转换后，该范围随孕周呈线性增加。在妊娠结局良好的孕妇中，雌激素与肌酐比值的log10下降超过该范围的40%是不常见的，提示胎儿胎盘功能受损。
