Gokel J M, Hübner G
Beitr Pathol. 1977 Oct;161(2):176-86. doi: 10.1016/s0005-8165(77)80096-6.
Fine structural analysis of 21 surgically removed specimens of Morbus Dupuytren (Dupuytren's contracture) in the cells of the proliferative phase revealed spindle-shaped or round, periodic banded structures of 1--1.5 micron size. These intracellular structures are surrounded by trilaminar membranes of 45 A continuous with membranes of the endoplasmic reticulum. The periodic banded structures display a light-dark pattern of 750--900 A and resemble with respect to periodicity and general morphology "fibrous long spacing" collagen. To date, "fibrous long spacing" collagen in human tissue has only been observed in the extracellular space, both in normal and pathologic conditions. Its formal pathogenesis is discussed.
对21例手术切除的杜普伊特伦病（杜普伊特伦挛缩症）增生期细胞标本进行的精细结构分析显示，存在大小为1 - 1.5微米的纺锤形或圆形、周期性带状结构。这些细胞内结构被45埃的三层膜所包围，该膜与内质网的膜相连。周期性带状结构呈现出750 - 900埃的明暗图案，在周期性和总体形态上类似于“纤维长间距”胶原。迄今为止，人类组织中的“纤维长间距”胶原仅在细胞外空间中被观察到，无论是在正常还是病理条件下。文中讨论了其确切的发病机制。
