Beilin L J, Eyeions D, Hatcher G, Knight G J, Munro-Faure A D, Anderson J
J Gen Physiol. 1966 Sep;50(1):75-88. doi: 10.1085/jgp.50.1.75.
The kinetics of sodium, movement into human red blood cells has been studied in vivo with (24)Na. When human serum albumin(-131)I is used to measure the percentage of plasma trapped in the packed red blood cells after centrifugation, approximately 30 % of red blood cell sodium is found to equilibrate immediately with plasma. It is concluded that this immediately exchangeable compartment of red blood cell sodium is an experimental artefact, associated with the use of labeled albumin for measuring plasma trapping. This immediately exchangeable fraction disappears when sucrose-(14)C is used to measure plasma trapping. The experimental results were examined by compartmental analysis, using an analogue computer. The results obtained, when plasma trapping was measured with sucrose-(14)C could be simulated by the use of models containing two compartments, arranged in series or in parallel. The errors of the techniques used and the possible physical basis for the results are discussed.
利用（24）Na在体内研究了钠进入人体红细胞的动力学。当使用人血清白蛋白（-131）I来测量离心后堆积红细胞中截留的血浆百分比时，发现约30%的红细胞钠能立即与血浆达到平衡。得出的结论是，红细胞钠的这个立即可交换部分是一种实验假象，与使用标记白蛋白测量血浆截留有关。当使用蔗糖-（14）C测量血浆截留时，这个立即可交换部分消失。使用模拟计算机通过房室分析来检验实验结果。当用蔗糖-（14）C测量血浆截留时所获得的结果，可以通过使用包含两个串联或并联房室的模型来模拟。讨论了所用技术的误差以及这些结果可能的物理基础。
