Rocklin R E
J Clin Invest. 1976 Apr;57(4):1051-8. doi: 10.1172/JCI108347.
Histamine, one of the mediators involved in the IgE-mediated reaction, was demonstrated to influence in vivo and in vitro components of cellular-immune reactions in orthochlorbenzoyl-bovine gamma globulin-immune guinea pigs. 10(-3) M histamine reduced by half the size of a delayed hypersensitivity skin test at 24 h. Inhibition of skin reactivity by histamine could be partially reversed by H-1 receptor antagonists such as chlorpheniramine and completely prevented by H-2 receptor antagonists such as burimamide. The histamine suppression of cutaneous delayed hypersensitivity could be accounted for in part by its inhibitory effect on certain lymphocyte responses including antigen-induced migration inhibitory factor (MIF) production and proliferation. At concentrations of 10(-3)-10(-5) M histamine reversibly inhibited MIF production and its action could be blocked by H-2 antagonists but not H-1 antagonists. Thus, lymphocytes bearing H-2 receptors modulate MIF production and probably lymphocyte proliferation as well. Histamine did not interfere with the macrophage response to preformed MIF. These studies indicate that immediate hypersensitivity reactions involving histamine release might influence the subsequent expression of cellular-immune reactions.
组胺是参与IgE介导反应的介质之一，已证实在邻氯苯甲酰 - 牛γ球蛋白免疫的豚鼠体内，它可影响细胞免疫反应的体内和体外成分。10⁻³M组胺可使24小时迟发型超敏皮肤试验的大小减半。组胺对皮肤反应性的抑制作用可被H-1受体拮抗剂如氯苯那敏部分逆转，并被H-2受体拮抗剂如布立马胺完全阻止。组胺对皮肤迟发型超敏反应的抑制作用部分可归因于其对某些淋巴细胞反应的抑制作用，包括抗原诱导的迁移抑制因子（MIF）产生和增殖。在10⁻³ - 10⁻⁵M浓度下，组胺可逆性抑制MIF产生，其作用可被H-2拮抗剂阻断，但不能被H-1拮抗剂阻断。因此，带有H-2受体的淋巴细胞调节MIF产生，可能也调节淋巴细胞增殖。组胺不干扰巨噬细胞对预先形成的MIF的反应。这些研究表明，涉及组胺释放的速发型超敏反应可能会影响细胞免疫反应的后续表达。
