T细胞对组织相容性-2抗原的反应。剂量反应动力学。
The response of T cells to histocompatibility-2 antigens. Dose-response kinetics.
作者信息
Gershon R K, Liebhaber S A
出版信息
J Exp Med. 1972 Jul 1;136(1):112-27. doi: 10.1084/jem.136.1.112.
The DNA synthetic response of a wide variety of parental thymocyte doses was studied in the lymphoid tissues of lethally irradiated F(1) mice. The response curves of the thymocytes were strikingly similar in shape to those of T cells responding to antigens, such as sheep red cells, which are more labile than the histocompatibility antigens of the F(1) host. The response was characterized by a dose-dependent latent period of 1-3 days, followed by a sharp increase in activity and a significant subsequent shutoff. Larger thymocyte doses tended to shorten the latent period. A comparison of the responses of different cell doses to one another indicated that the response usually simulated a suppressed first-order reaction. However, occasional multiple order reactions were observed. We have interpreted these data to indicate that both positive and negative interactions occur between thymocytes, without the mediation of B cell products such as conventional antibodies.
在致死性照射的F(1)小鼠的淋巴组织中，研究了多种亲代胸腺细胞剂量的DNA合成反应。胸腺细胞的反应曲线在形状上与T细胞对抗原（如绵羊红细胞）的反应曲线惊人地相似，绵羊红细胞比F(1)宿主的组织相容性抗原更不稳定。该反应的特征是1-3天的剂量依赖性潜伏期，随后活性急剧增加，随后显著关闭。较大的胸腺细胞剂量倾向于缩短潜伏期。不同细胞剂量之间的反应比较表明，该反应通常模拟受抑制的一级反应。然而，偶尔也观察到多级反应。我们对这些数据的解释是，胸腺细胞之间发生了正负相互作用，而没有B细胞产物（如传统抗体）的介导。
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