Nagy Z M, Porada K J, Monsour A P
Dev Psychobiol. 1980 Jul;13(4):373-84. doi: 10.1002/dev.420130404.
To assess the effects of early postnatal undernutrition upon the developing abilities of infant and juvenile mice to acquire and retain a passive-avoidance response, we reared mice following birth in either "normally nourished" or "undernourished" conditions by maintaining litter sizes of 6 or 16, respectively. At ages ranging from 7 to 21 days, mice from each nutritional condition were trained to withhold stepping off from a small vibrating platform in order to avoid shock. Following training to a common criterion, separate groups of mice were retained to the same criterion either 1 or 24 hr later. From the comparisons with yoked control groups at each age and retention interval, we conclude that although undernutrition results in some age-related differences in the ability to withhold responding, these are quite small during acquisition within each age group. In contrast, the retention data suggest that undernutrition delayed the development of both short- and long-term memory abilities on this task. In general, these results are similar to earlier data involving discriminated shock-escape wherein undernutrition had little apparent effect upon acquisition at the early ages but rather marked effects upon developing memory system.
为了评估出生后早期营养不良对幼鼠获得和保持被动回避反应能力发展的影响，我们在小鼠出生后分别通过维持每组6只或16只的窝仔数，将其饲养在“营养正常”或“营养不良”的条件下。在7至21日龄期间，对每种营养条件下的小鼠进行训练，使其避免从小型振动平台上跳下以避免电击。在训练达到共同标准后，将不同组的小鼠在1小时或24小时后保持在相同标准。通过与每个年龄和保持间隔的配对对照组进行比较，我们得出结论，虽然营养不良会导致在抑制反应能力上出现一些与年龄相关的差异，但在每个年龄组的习得过程中这些差异相当小。相比之下，保持数据表明营养不良会延迟在此任务上短期和长期记忆能力的发展。总体而言，这些结果与早期涉及辨别性电击逃避的研究数据相似，即营养不良在早期对习得几乎没有明显影响，但对记忆系统的发展有显著影响。
