Nagy Z M, Anderson J A, Mazzaferri T A
Dev Psychobiol. 1976 Sep;9(5):447-58. doi: 10.1002/dev.420090507.
Nine-day-old S-W mice receiving deep body hypothermia or hyperthermia immediately after escape training were retested 1 or 24 hr later. Results indicated that hypothermia impaired 24-hr retention but had no effect upon 1-hr memory. Hyperthermia had no effect, with the mice demonstrating retention of the escape response at both retest intervals. In Experiment 2, administration of hypothermia or hyperthermia 23 hr after original training had no effect upon memory nor did either treatment produce motoric deficits upon retest 1 hr following thermal exposure. Experiment 3 indicated that hypothermia administered immediately after training produced retention deficits directly related to amount of body temperature reduction following hypothermia. These data are similar to those obtained with adult mice and suggest that memory processes occurring in 9-day-old mice may represent the onset of functioning of processes underlying adult long-term memory.
在逃避训练后立即接受深度体温过低或体温过高处理的9日龄S-W小鼠，在1小时或24小时后重新接受测试。结果表明，体温过低会损害24小时的记忆保持，但对1小时的记忆没有影响。体温过高则没有影响，小鼠在两个重新测试间隔期均表现出逃避反应的记忆保持。在实验2中，在初次训练23小时后给予体温过低或体温过高处理对记忆没有影响，且两种处理在热暴露后1小时重新测试时均未产生运动缺陷。实验3表明，训练后立即给予体温过低处理会产生与体温过低后体温降低量直接相关的记忆保持缺陷。这些数据与在成年小鼠中获得的数据相似，表明9日龄小鼠中发生的记忆过程可能代表成年长期记忆基础过程开始发挥作用。
