Mori H, Ushimaru Y, Tanaka T, Hirono I
Gan. 1977 Dec;68(6):841-5.
Effect of carbon tetrachloride on the carcinogenicity of the flower stalk of Petasites japonicus was examined in 3 experimental groups of inbred strain ACI rats. Group 1 received 4% petasites diet until termination of the experiment and intragastric administration of CC14, once every 2 weeks, for a total of 15 times. Group 2 received only 4% petasites diet, and Group 3 CC14 and a basal diet. Another group of rats which were fed a basal diet served as a control groups. Both Group 1 and 2 showed the same incidence of hemangioendothelial sarcoma of the liver (6/22). However, the incidence of hyperplastic liver nodules (19/22) and liver cell adenomas (8/22) in Group 1 was significantly higher than in Group 2 (2/22, 0/22). No hyperplastic liver nodules or liver cell adenomas were noted in Group 3. These results indicate that the administration of CC14 probably enhanced the carcinogenic activity of Petasites japonicus in hepatocellular tumorigenesis. Three hemangioendothelial sarcomas of the liver induced in rats in Groups 1 and 2 were subcutaneously transplanted and established as transplantable tumor lines.
在3组近交系ACI大鼠实验中，研究了四氯化碳对蜂斗菜叶柄致癌性的影响。第1组在实验结束前接受4%蜂斗菜饮食，并每2周进行一次四氯化碳灌胃，共15次。第2组仅接受4%蜂斗菜饮食，第3组接受四氯化碳和基础饮食。另一组喂食基础饮食的大鼠作为对照组。第1组和第2组肝血管内皮肉瘤的发生率相同（6/22）。然而，第1组肝增生性结节（19/22）和肝细胞腺瘤（8/22）的发生率显著高于第2组（2/22，0/22）。第3组未发现肝增生性结节或肝细胞腺瘤。这些结果表明，四氯化碳的给药可能增强了蜂斗菜在肝细胞肿瘤发生中的致癌活性。将第1组和第2组大鼠诱导产生的3例肝血管内皮肉瘤进行皮下移植，建立可移植肿瘤系。
