Zharova E A
Kardiologiia. 1977 Oct;17(10):46-50.
Changes are observed in the renal kallikrein-kinin system in hypertensive disease, which are displayed by compensatory increase in its activity in patients with labile hypertension and decrease in the activity of this system in patients with a stable stage of the disease. An inadequate reaction to a load experienced from walking or from a reduced volume of extracellular fluid and sodium balance in the body was noted in all stages. The absence of a reaction or the inhibition of the activity of the renal kallikrein-kinin system in response to the intake of furosemid may be a manifestation of its altered sensitivity to the electrolyte shifts in the organism and the decrease in the volume of extracellular fluid. The kallikrein-kinin system is concerned with the noted shifts in renal function linked with the transport of sodium and water in patients with the labile stage of the disease, to which the correlative connection between kallikrein excretion and natriuresis and urine excretion attests. It is suggested that the renal kallikrein-kinin system in patients with the initial stage of hypertensive disease contributes to the adaptation of renal function to the altered conditions of hemodynamics and the increased activity of the renin-angiotensin-aldosterone system.
在高血压疾病中可观察到肾脏激肽释放酶 - 激肽系统的变化，表现为在不稳定高血压患者中该系统活性代偿性增加，而在疾病稳定期患者中该系统活性降低。在所有阶段均发现对行走或细胞外液量减少及体内钠平衡所产生的负荷反应不足。对呋塞米摄入无反应或肾脏激肽释放酶 - 激肽系统活性受抑制，可能是其对机体电解质变化敏感性改变及细胞外液量减少的一种表现。激肽释放酶 - 激肽系统与疾病不稳定期患者肾脏功能中与钠和水转运相关的上述变化有关，激肽释放酶排泄与利钠及尿排泄之间的相关性联系证明了这一点。有人认为，高血压疾病初期患者的肾脏激肽释放酶 - 激肽系统有助于肾脏功能适应血流动力学改变及肾素 - 血管紧张素 - 醛固酮系统活性增加的情况。
