Zharova E A, Sokolova R I, Nekrasova A A
Biull Eksp Biol Med. 1977 Aug;84(8):141-3.
Water and saline loading and Lasix administration lead to the intensification of the renal kallikrein-kinin system activity in rats. A positive correlation between the kallikrein excretion, urine volume and "osmotically free water" clearance was established in water and osmotic diuresis. There was the highest amount of kallikrein excreted by the kidneys during the "escape" phenomenon after saline loading. Kallikrein excretion correlated positively with sodium excretion in osmotic diuresis. The role played by the kallikrein-kinin system in control of diuresis, sodium excretion and concentrating capacity of the kidneys is discussed.
水和盐水负荷以及速尿给药会导致大鼠肾激肽释放酶-激肽系统活性增强。在水利尿和渗透性利尿过程中，激肽释放酶排泄、尿量与“渗透自由水”清除率之间建立了正相关关系。盐水负荷后“逃逸”现象期间，肾脏排泄的激肽释放酶量最高。在渗透性利尿中，激肽释放酶排泄与钠排泄呈正相关。本文讨论了激肽释放酶-激肽系统在控制利尿、钠排泄和肾脏浓缩能力中所起的作用。
