[Change in the state of the renal kallikrein-kinin system in hypertension].

The work discusses the results of the investigation of kallikrein excretion in the urine in healthy individuals and in patients with hypertensive disease examined under similar conditions. The following tests were undertaken: tests for tolerance to physical exercise (walking and exercise on the bicycle ergometer) and to emotional stress and test with decreased extracellular fluid volume and sodium content (acute and long-term furosemid administration) or with their increase (intravenous salt infusion). Functional reorganization of the renal kallikrein-kinin system was revealed in patients with hypertensive disease. It was expressed in an increase in the activity of this humoral system in patients with the initial stage of the disease when they were examined in a state of physical rest and its decrease in all stages of the disease when examined during physical activity. A reduction was noted in the reaction of the kallikrein-kinin system of the kidneys to stimulation associated with acute or long-term (stage IIB) decrease in volume. A simultaneous increase in kallikrein excretion in the urine in response to acute and long-term salt tolerance tests was noted in hypertensive disease.