Nekrasova A A
Kardiologiia. 1980 Sep;20(9):19-24.
The work discusses the results of the investigation of kallikrein excretion in the urine in healthy individuals and in patients with hypertensive disease examined under similar conditions. The following tests were undertaken: tests for tolerance to physical exercise (walking and exercise on the bicycle ergometer) and to emotional stress and test with decreased extracellular fluid volume and sodium content (acute and long-term furosemid administration) or with their increase (intravenous salt infusion). Functional reorganization of the renal kallikrein-kinin system was revealed in patients with hypertensive disease. It was expressed in an increase in the activity of this humoral system in patients with the initial stage of the disease when they were examined in a state of physical rest and its decrease in all stages of the disease when examined during physical activity. A reduction was noted in the reaction of the kallikrein-kinin system of the kidneys to stimulation associated with acute or long-term (stage IIB) decrease in volume. A simultaneous increase in kallikrein excretion in the urine in response to acute and long-term salt tolerance tests was noted in hypertensive disease.
该研究探讨了在相似条件下对健康个体和高血压患者尿液中激肽释放酶排泄情况的调查结果。进行了以下测试：身体运动耐受性测试（步行和自行车测力计运动）、情绪应激测试，以及细胞外液量和钠含量降低（急性和长期使用速尿）或增加（静脉输注盐水）的测试。高血压患者的肾激肽释放酶 - 激肽系统出现了功能重组。表现为在疾病初期患者处于身体休息状态时该体液系统活性增加，而在疾病各阶段进行身体活动时活性降低。肾脏激肽释放酶 - 激肽系统对与急性或长期（IIB期）容量减少相关刺激的反应减弱。在高血压疾病中，还注意到对急性和长期盐耐受性测试的反应中，尿液中激肽释放酶排泄量同时增加。
