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甲状腺素和促黄体生成素对脂肪组织、睾丸及肾上腺中一些与脂质生成有关的酶的影响。

Influence of thyroxine and luteinizing hormone on some enzymes concerned with lopogenesis in adipose tissue, testis and adrenal gland.

作者信息

Brown J, McLean P, Greenbaum A L

出版信息

Biochem J. 1966 Oct;101(1):197-203. doi: 10.1042/bj1010197.

DOI:10.1042/bj1010197
PMID:6008341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1270083/
Abstract

The activities of hexokinase, citrate-cleavage enzyme, ;malic enzyme' and NADP-linked isocitrate dehydrogenase have been measured in the adipose tissue, testes and adrenals of normal rats, hypophysectomized rats and hypophysectomized rats treated with either thyroxine or thyroxine plus luteinizing hormone. Hypophysectomy reduced the activity of all four enzymes in all three tissues. Thyroxine alone restored the activity of all four enzymes in adipose tissue towards normal but failed to do so in either testes or adrenals. Thyroxine and luteinizing hormone restored the citrate-cleavage enzyme activity of testes and increased the activity of hexokinase from the low value after hypophysectomy. Neither ;malic enzyme' nor isocitrate dehydrogenase was increased by thyroxine or thyroxine and luteinizing hormone in testes. The differential stimulation of enzyme activity by thyroxine in the different tissues suggests thyroxine as having a special significance in adipose-tissue lipogenesis.

摘要

已测定正常大鼠、垂体切除大鼠以及用甲状腺素或甲状腺素加促黄体生成素治疗的垂体切除大鼠的脂肪组织、睾丸和肾上腺中己糖激酶、柠檬酸裂解酶、“苹果酸酶”和NADP连接的异柠檬酸脱氢酶的活性。垂体切除降低了所有三种组织中这四种酶的活性。单独使用甲状腺素可使脂肪组织中所有四种酶的活性恢复正常，但在睾丸或肾上腺中则未能如此。甲状腺素和促黄体生成素恢复了睾丸中柠檬酸裂解酶的活性，并使垂体切除后己糖激酶的活性从低值增加。在睾丸中，甲状腺素或甲状腺素与促黄体生成素均未增加“苹果酸酶”或异柠檬酸脱氢酶的活性。甲状腺素在不同组织中对酶活性的差异刺激表明，甲状腺素在脂肪组织脂肪生成中具有特殊意义。

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CITRATE AND THE CONVERSION OF CARBOHYDATE INTO FAT. ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF NORMAL AND DIABETIC RATS.柠檬酸盐与碳水化合物向脂肪的转化。正常及糖尿病大鼠肝脏中柠檬酸裂解酶和乙酸硫激酶的活性
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