主要组织相容性抗原与疾病的关系。与人类沙粒病毒病的可能关联。
Relationship between major histocompatibility antigens and disease. Possible associations with human arenavirus diseases.
作者信息
Oldstone M B
出版信息
Bull World Health Organ. 1975;52(4-6):479-86.
Histocompatibility antigens, virus infections, and disease are discussed relative to avenues of research in humans with arenavirus infections. The data implicating a relationship between histocompatibility complexes in man and animals and diseases of the central nervous system are reviewed. Histocompatibility antigens may share common antigenic determinants with viruses, act as receptor sites for attachment of viruses, and be altered by viruses. In addition, genes regulating immune responses to a variety of natural and synthetic antigens are linked, in many species, to the major histocompatibility complex. Since injury associated with virus infections may be largely due to the activity of the immune system, study of immune response genes may provide insight into understanding resistance to disease. Further, histoincompatibility reactions can activate latent viruses with resultant disease.
本文讨论了组织相容性抗原、病毒感染与疾病之间的关系，这些内容与人类感染沙粒病毒的研究途径相关。文中回顾了关于人类和动物组织相容性复合体与中枢神经系统疾病之间关系的数据。组织相容性抗原可能与病毒共享共同的抗原决定簇，充当病毒附着的受体位点，并被病毒改变。此外，在许多物种中，调节对各种天然和合成抗原免疫反应的基因与主要组织相容性复合体相关联。由于病毒感染相关的损伤可能很大程度上归因于免疫系统的活动，对免疫反应基因的研究可能有助于深入理解疾病抗性。此外，组织不相容性反应可激活潜伏病毒并导致疾病。
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