Ranney E K, Norman M G, Silver M D
Can Med Assoc J. 1967 Feb 25;96(8):445-50.
Four adults had varicella pneumonitis. All developed respiratory symptoms within a week of the exanthem. Cough and/or dyspnea, cyanosis and chest pain were common. Radiological signs of disease were more marked than physical signs. A slight polymorphonuclear leukocytosis and normal sputum culture were usual. One man with mild symptoms recovered. Two women, one pregnant, had severe symptoms and died. A second man succumbed to secondary bacterial pneumonia. The lungs in fatal cases showed interstitial pneumonitis with mononuclear cell infiltrate, focal areas of necrosis, and acidophilic inclusion bodies in two cases. Patients received oxygen, antibiotics and, in one instance, corticosteroid therapy. The value of antibiotics and corticosteroid treatment is questionable. Use of gamma globulin in preventing varicella pneumonitis is mentioned and residual pulmonary changes are discussed.
四名成年人患了水痘肺炎。所有人在皮疹出现后的一周内都出现了呼吸道症状。咳嗽和/或呼吸困难、发绀和胸痛很常见。疾病的放射学征象比体征更明显。通常有轻微的多形核白细胞增多，痰培养正常。一名症状较轻的男性康复了。两名女性，其中一名怀孕，症状严重并死亡。第二名男性死于继发性细菌性肺炎。致命病例的肺部显示间质性肺炎，伴有单核细胞浸润、局灶性坏死区域，两例出现嗜酸性包涵体。患者接受了氧气、抗生素治疗，其中一例还接受了皮质类固醇治疗。抗生素和皮质类固醇治疗的价值值得怀疑。文中提到了使用丙种球蛋白预防水痘肺炎，并讨论了肺部的残留变化。
