兔乳酸脱氢酶同工酶：pH对活性的影响。
Rabbit lactate dehydrogenase isozymes: effect of pH on activity.
作者信息
Fritz P J
出版信息
Science. 1967 Apr 7;156(3771):82-3. doi: 10.1126/science.156.3771.82.
PMID:6020045
Abstract
The ability of lactate dehydrogenase isozyme five from rabbit skeletal muscle to catalyze pyruvate reduction is extremely sensitive to changes of pH within the range of 6.2 to 7.8. The activity of lactate dehydrogenase isozyme one from rabbit heart is virtually unaffected by changes of pH within the same range. Isozyme five is activated by low concentrations of oxalacetate and inhibited by higher concentrations, but other substrates of the citric acid cycle have no effect.
摘要
来自兔骨骼肌的乳酸脱氢酶同工酶5催化丙酮酸还原的能力在6.2至7.8的pH范围内对pH变化极为敏感。来自兔心脏的乳酸脱氢酶同工酶1的活性在相同pH范围内实际上不受pH变化的影响。同工酶5被低浓度的草酰乙酸激活，而被高浓度抑制，但柠檬酸循环的其他底物没有影响。
相似文献
1
Rabbit lactate dehydrogenase isozymes: effect of pH on activity.兔乳酸脱氢酶同工酶：pH对活性的影响。
Science. 1967 Apr 7;156(3771):82-3. doi: 10.1126/science.156.3771.82.
2
Rabbit muscle lactate dehydrogenase 5; a regulatory enzyme.兔肌肉乳酸脱氢酶5；一种调节酶。
Science. 1965 Oct 15;150(3694):364-6. doi: 10.1126/science.150.3694.364.
3
Effects of pH, ionic strength, and metabolic intermediates on the rates of heat inactivation of lactate dehydrogenase isozymes.pH值、离子强度和代谢中间产物对乳酸脱氢酶同工酶热失活速率的影响。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1317-24. doi: 10.1073/pnas.56.4.1317.
4
Substrate and product inhibition of rabbit muscle lactic dehydrogenase heart (H4) and muscle (M4) isozymes.兔肌肉乳酸脱氢酶心脏型（H4）和肌肉型（M4）同工酶的底物和产物抑制作用。
J Biol Chem. 1966 Apr 10;241(7):1462-7.
5
Kinetic mechanism of guinea-pig skeletal muscle lactate dehydrogenase (M4) with oxaloacetate-NADH and pyruvate-NADH as substrates.以草酰乙酸 - 还原型辅酶Ⅰ和丙酮酸 - 还原型辅酶Ⅰ为底物的豚鼠骨骼肌乳酸脱氢酶（M4）的动力学机制
Int J Biochem. 1981;13(6):727-31. doi: 10.1016/0020-711x(81)90042-2.
6
[Characteristics of lactate dehydrogenase isoenzymes of loach differentiated tissues and eggs].[泥鳅不同组织及卵中乳酸脱氢酶同工酶的特征]
Biokhimiia. 1978 Dec;43(12):2137-42.
7
[Functional interrelations between isozymes of dehydrogenases in the intact and denervated rabbit muscles].[完整及去神经支配兔肌肉中脱氢酶同工酶之间的功能相互关系]
Biokhimiia. 1977 Feb;42(2):311-9.
8
9
Lactate and pyruvate concentrations in exercised ischemic canine muscle: relationship of tissue substrate level to lactate dehydrogenase isozyme pattern.运动性缺血犬肌肉中的乳酸和丙酮酸浓度：组织底物水平与乳酸脱氢酶同工酶模式的关系。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):756-62. doi: 10.1073/pnas.55.4.756.
10
Lactate dehydrogenases of Atlantic hagfish: physiological and evolutionary implications of a primitive heart isozyme.
Science. 1980 Feb 15;207(4432):769-70. doi: 10.1126/science.7352286.
引用本文的文献
1
Bioelectrocatalysis with a palladium membrane reactor.钯膜反应器中的生物电化学催化。
Nat Commun. 2023 Mar 31;14(1):1814. doi: 10.1038/s41467-023-37257-7.
2
A survey on the formation and localization of secondary isozymes in mammalia.哺乳动物中次生同工酶的形成与定位研究
Hum Genet. 1980;56(2):129-55. doi: 10.1007/BF00295687.
3
Effects of carbon dioxide, bicarbonate and pH on lactate and pyruvate in the brain of rats.二氧化碳、碳酸氢盐和pH值对大鼠脑内乳酸和丙酮酸的影响。
Pflugers Arch. 1970;314(4):292-311. doi: 10.1007/BF00592288.
Zotero 插件