Ayitey-Smith E, Gbewonyo A J
West Afr J Pharmacol Drug Res. 1977 Jun;4(1):7-15.
Effects of prolonged chloroquine administration on ultrastructure of the heart was studied in albino rats. Chloroquine when administered orally (30-40 mg/kg/day) or subcutaneously (20 mg/kg/day) for two to four weeks, produced marked degenerative changes in the mitochondria and myofibrils of the myocardium. The mitochondria were more susceptible to the toxic effect of chloroquine than were other cell organelles. Moreover, the cytotoxic effect of the drug appeared to be related to total dose. Chloroquine-induced abnormalities were reversible on terminating medication. These results indicate that prolonged chloroquine administration impairs ultrastructure of the myocardium.
在白化大鼠中研究了长期给予氯喹对心脏超微结构的影响。当口服（30 - 40毫克/千克/天）或皮下注射（20毫克/千克/天）氯喹两至四周时，心肌的线粒体和肌原纤维出现明显的退行性变化。线粒体比其他细胞器更容易受到氯喹的毒性作用影响。此外，药物的细胞毒性作用似乎与总剂量有关。停止用药后，氯喹诱导的异常是可逆的。这些结果表明，长期给予氯喹会损害心肌的超微结构。
