Bielnik K, Szram S
Department of Ultrastructural Pathology Military Medical School, Lódź.
Patol Pol. 1992;43(4):157-9.
The authors carried out ultrastructural studies of the myocardial sections from inbred Wistar rats in the course of acute experimental poisoning with ethylene glycol. It was shown that slight mitochondrial swelling with clearing of the matrix, myofibrillar edema with decreased electron density of the sarcoplasma and widening of channels of the smooth intraplasmatic reticulum were visible as early as at 12 hours after intoxication with no changes in light microscopy. The changes were located mainly in the subendocardial layer of the ventricles and papillary muscles. At later stages of the experimental ultrastructural changes markedly progressed. Mitochondrial swelling enhanced with destruction of mitochondrial crests, myelin-like figures formed, myofibrillar necrosis and contraction bands developed and segmental or complete dissection of the intercalated disk edges appeared. The chages were scattered all over the myocardium predominating in the subendocardial layer and papillary muscles.
作者对近交系Wistar大鼠在乙二醇急性实验性中毒过程中的心肌切片进行了超微结构研究。结果表明，早在中毒后12小时，即可见线粒体轻度肿胀，基质透亮，肌原纤维水肿，肌浆电子密度降低，胞质内滑面内质网通道增宽，而光学显微镜下无变化。这些变化主要位于心室的心内膜下层和乳头肌。在实验后期，超微结构变化明显进展。线粒体肿胀加剧，嵴破坏，形成髓鞘样结构，出现肌原纤维坏死和收缩带，闰盘边缘出现节段性或完全分离。这些变化散在分布于整个心肌，在心内膜下层和乳头肌更为明显。
