异源Fc和Fab免疫球蛋白片段在兔、豚鼠和大鼠中的免疫原性。
Immunogenicity of heterologous Fc and Fab immunoglobulin fragments in rabbits, guinea-pigs and rats.
作者信息
Binaghi R A, Oriol R, Boussac-Aron Y
出版信息
Immunology. 1967 Jul;13(1):63-9.
Abstract
Rabbits, guinea-pigs and rats were immunized with various heterologous 7S and 19S immunoglobulins from each other and man, and the antisera obtained were studied by immunoelectrophoresis. Rabbits produced antibodies against the Fc and the Fab fragments of the immunoglobulin injected, while guinea-pigs and rats only produced anti-Fc antibodies. The fact that guinea-pigs and rats only respond to the specific determinants of each class of immunoglobulin provides a simple method for the preparation of class-specific antisera.
摘要
用来自兔、豚鼠和大鼠以及人类的各种异源7S和19S免疫球蛋白分别对兔、豚鼠和大鼠进行免疫，并通过免疫电泳研究获得的抗血清。兔产生针对所注射免疫球蛋白的Fc片段和Fab片段的抗体，而豚鼠和大鼠仅产生抗Fc抗体。豚鼠和大鼠仅对每类免疫球蛋白的特异性决定簇产生反应，这一事实为制备类特异性抗血清提供了一种简单方法。
Zotero 插件