小鼠和大鼠肥大细胞的IgE交叉致敏作用及抗原关系。
Mouse and rat IgE Cross-sensitization of mast cells and antigenic relationships.
作者信息
Prouvost-Danon A, Wyczolkowska J, Binaghi R, Abadie A
出版信息
Immunology. 1975 Jul;29(1):151-62.
Mouse and rat IgE fix firmly to the peritoneal mast cells from the other species, sensitizing them for anaphylactic reaction. Sensitization with IgE can be demonstrated by inducing degranulation either with specific antigens or with corresponding anti-IgE. Sensitization of rat mast cells by mouse IgE antibodies is more easily obtained than that of mouse mast cells by rat IgE antibodies. In this case, anti-IgE-induced degranulation is higher than antigen-induced degranulation. Heterologous sensitization by IgE is time requiring and temperature-dependent. Its kinetics depend upon IgE concentration. Cross-reactions between IgE from one species and anti-IgE from another species have been observed: anti-IgE for one species is able to neutralize PCA reaginic activity of sera from the other species; anti-rat IgE induces degranulation of mouse actively sensitized mast cells. The results suggest strongly that there exists a structural and functional similarity between the IgE molecules from the two species.
小鼠和大鼠的IgE能牢固地结合到另一物种的腹膜肥大细胞上，使其对过敏反应敏感。用特异性抗原或相应的抗IgE诱导脱颗粒可证明IgE致敏。小鼠IgE抗体对大鼠肥大细胞的致敏比大鼠IgE抗体对小鼠肥大细胞的致敏更容易实现。在这种情况下，抗IgE诱导的脱颗粒高于抗原诱导的脱颗粒。IgE的异源致敏需要时间且依赖温度。其动力学取决于IgE浓度。已观察到一种物种的IgE与另一种物种的抗IgE之间的交叉反应：针对一种物种的抗IgE能够中和另一种物种血清的PCA反应素活性；抗大鼠IgE可诱导主动致敏的小鼠肥大细胞脱颗粒。结果有力地表明，这两个物种的IgE分子之间存在结构和功能上的相似性。
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