Penny R, Olambiwonnu N O, Frasier S D
Am J Med Sci. 1977 Sep-Oct;274(2):203-6. doi: 10.1097/00000441-197709000-00013.
The 24-hour urinary excretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) was determined for 30 days in an 8.3-year-old girl with isosexual precocity and for 25 days in a normal 11.9-year-old girl. The pattern of daily variation in urinary LH and FSH excretion observed in the girl with sexual precocity was similar to that of the normal menstrual cycle. The LH and FSH midcycle peaks were 132.5 IU/24 hours and 26.3 IU/24 hours, respectively. Excluding the midcycle peak, the daily excretion of LH was 28.4 +/- 9.3 (SD) IU/24 hours, and the excretion of FSH was 8.9 +/- 1.9 (SD) IU/24 hours, values comparable to those of normal adult females. In contrast, the daily excretion of LH in the normal 11.9-year-old girl was 6.9 +/- 1.1 (SD) IU/24 hours and FSH excretion was 3.9 +/- 0.9 (SD) IU/24 hours. No LH or FSH surge was observed. The data are consistent with early maturation of the hypothalamic-pituitary-gonadal axis in idiopathic isosexual precocity.
对一名8.3岁同性性早熟女孩测定了30天促黄体生成素（LH）和促卵泡生成素（FSH）的24小时尿排泄量，并对一名正常的11.9岁女孩测定了25天。在性早熟女孩中观察到的尿LH和FSH排泄的每日变化模式与正常月经周期相似。LH和FSH的周期中期峰值分别为132.5 IU/24小时和26.3 IU/24小时。排除周期中期峰值后，LH的每日排泄量为28.4±9.3（标准差）IU/24小时，FSH的排泄量为8.9±1.9（标准差）IU/24小时，这些值与正常成年女性相当。相比之下，正常的11.9岁女孩LH的每日排泄量为6.9±1.1（标准差）IU/24小时，FSH排泄量为3.9±0.9（标准差）IU/24小时。未观察到LH或FSH高峰。这些数据与特发性同性性早熟中下丘脑-垂体-性腺轴的过早成熟一致。
