• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

神经刺激磷酸肽（神经侧，物质B）在中枢神经系统中的区域分布。

The regional distribution of the nerve-stimulating phosphopeptide (nerveside, substance B) in the central nervous system.

作者信息

Toh C C

出版信息

J Physiol. 1967 Feb;188(3):451-6. doi: 10.1113/jphysiol.1967.sp008149.

DOI:10.1113/jphysiol.1967.sp008149
PMID:6032208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1396016/
Abstract
  1. The nerve-stimulating phosphopeptide, nerveside, is present mainly in the cerebrum and brain stem, while the cerebellum contains only a trace amount of it.2. Nerveside is uniformly distributed over all parts of the cerebral cortex.3. The cerebral cortex contains the greatest concentration of nerveside. If the nerveside activity of 1 g cerebral cortex is expressed as 100 then the relative activities of the other parts of the C.N.S. are hippocampus 41, caudate nucleus 21, diencephalon (without hypothalamus) 24, midbrain 19, pons 7, medulla 12 and cerebellum 6.4. The nerveside activity of the hypothalamus is the same as that of the cerebral cortex.5. The pattern of distribution of nerveside in the C.N.S. suggests that it may be part of a corticipetal or corticifugal system.
摘要

  1. 神经刺激磷酸肽nerveside主要存在于大脑和脑干中，而小脑仅含有微量的该物质。

  2. Nerveside均匀分布于大脑皮层的所有部位。

  3. 大脑皮层中nerveside的浓度最高。若将1克大脑皮层的nerveside活性表示为100，那么中枢神经系统其他部位的相对活性分别为：海马体41、尾状核21、间脑（不含下丘脑）24、中脑19、脑桥7、延髓12以及小脑6。

  4. 下丘脑的nerveside活性与大脑皮层相同。

  5. Nerveside在中枢神经系统中的分布模式表明，它可能是向心或离心系统的一部分。

相似文献

1
The regional distribution of the nerve-stimulating phosphopeptide (nerveside, substance B) in the central nervous system.神经刺激磷酸肽（神经侧，物质B）在中枢神经系统中的区域分布。
J Physiol. 1967 Feb;188(3):451-6. doi: 10.1113/jphysiol.1967.sp008149.
2
PREPARATION OF A NERVE-STIMULATING PHOSPHOPEPTIDE (SUBSTANCE B, NERVESIDE) IN BRAIN EXTRACTS AND AN ENZYME IN BRAIN WHICH INACTIVATES IT.脑提取物中神经刺激磷肽（物质B，神经侧）的制备以及脑中使其失活的一种酶
J Physiol. 1964 Oct;173(3):420-30. doi: 10.1113/jphysiol.1964.sp007465.
3
The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system.狗脑中四种前列腺素的鉴定及其在中枢神经系统中的区域分布。
J Physiol. 1968 Apr;195(3):731-41. doi: 10.1113/jphysiol.1968.sp008485.
4
The action of nerveside, a peptide extracted from brain, on myenteric ganglia in Auerbach's plexus.神经肽（一种从大脑中提取的肽）对奥尔巴赫神经丛中肠肌间神经节的作用。
J Physiol. 1971 Mar;213(3):571-80. doi: 10.1113/jphysiol.1971.sp009401.
5
The inhibitory effect of convulsant agents on the enzyme in brain which inactivates nerveside.惊厥剂对脑中使神经递质失活的酶的抑制作用。
J Physiol. 1969 Jul;203(1):83-91. doi: 10.1113/jphysiol.1969.sp008851.
6
Effects of intracerebroventricularly injected "nerveside" on free behaviour and EEG activity of rats. A pilot study.脑室内注射“神经侧”对大鼠自由行为和脑电图活动的影响。一项初步研究。
Arch Int Pharmacodyn Ther. 1979 Jun;239(2):221-9.
7
Resting and stimulated respiration in vitro in the central nervous system. Regional distribution and relation to cell density.中枢神经系统体外静息和刺激呼吸。区域分布及其与细胞密度的关系。
Biochem J. 1967 Nov;105(2):831-5. doi: 10.1042/bj1050831.
8
The nature and distribution of prostaglandins in the central nervous system of the dog.前列腺素在犬中枢神经系统中的性质与分布。
J Physiol. 1967 Jul;191(2):134P-135P.
9
Regional changes in amino acid composition during anesthesia in the central nervous system of rats.大鼠中枢神经系统麻醉期间氨基酸组成的区域变化。
Proc West Pharmacol Soc. 1966;9:52-3.
10
The metabolism and distribution of penoline in rat brain.培诺林在大鼠脑中的代谢与分布
Biochem Pharmacol. 1968 Nov;17(11):2365-6. doi: 10.1016/0006-2952(68)90045-2.

引用本文的文献

1
Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1.膳食黄烷酮 α-倒捻子素通过稳定 SHP1 抑制 STAT3 信号通路抑制肝癌的抗癌活性。
Cell Death Dis. 2020 Jan 24;11(1):63. doi: 10.1038/s41419-020-2227-4.
2
The action of nerveside, a peptide extracted from brain, on myenteric ganglia in Auerbach's plexus.神经肽（一种从大脑中提取的肽）对奥尔巴赫神经丛中肠肌间神经节的作用。
J Physiol. 1971 Mar;213(3):571-80. doi: 10.1113/jphysiol.1971.sp009401.
3
The inhibitory effect of convulsant agents on the enzyme in brain which inactivates nerveside.惊厥剂对脑中使神经递质失活的酶的抑制作用。
J Physiol. 1969 Jul;203(1):83-91. doi: 10.1113/jphysiol.1969.sp008851.

本文引用的文献

1
HUMORAL TRANSMISSION OF SLEEP AND WAKEFULNESS. 3. HEMODIALYSIS OF ACTIVATING HUMORS DURING STIMULATION OF THE MIDBRAIN RETICULAR SYSTEM.
Pflugers Arch Gesamte Physiol Menschen Tiere. 1965 Feb 5;283:17-25. doi: 10.1007/BF00363297.
2
PREPARATION OF A NERVE-STIMULATING PHOSPHOPEPTIDE (SUBSTANCE B, NERVESIDE) IN BRAIN EXTRACTS AND AN ENZYME IN BRAIN WHICH INACTIVATES IT.脑提取物中神经刺激磷肽（物质B，神经侧）的制备以及脑中使其失活的一种酶
J Physiol. 1964 Oct;173(3):420-30. doi: 10.1113/jphysiol.1964.sp007465.
3
Biologically active substances in brain extracts.脑提取物中的生物活性物质。
J Physiol. 1963 Jan;165(1):47-61. doi: 10.1113/jphysiol.1963.sp007041.