狗脑中四种前列腺素的鉴定及其在中枢神经系统中的区域分布。
The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system.
作者信息
Holmes S W, Horton E W
出版信息
J Physiol. 1968 Apr;195(3):731-41. doi: 10.1113/jphysiol.1968.sp008485.
Abstract
- Experiments were carried out to determine whether the prostaglandins, which have been identified as natural constituents of the brain, are widely distributed or concentrated in special regions of the central nervous system.2. Prostaglandins E(1), E(2), F(1alpha) and F(2alpha) have been identified in dog brain using solvent partition, column and thin layer chromatographic and bio-assay techniques.3. Each of these prostaglandins is distributed throughout all regions of the central nervous system investigated (cortex, hippocampus, caudate nucleus, hypothalamus, cerebellum, medulla and pons, cortical white matter and spinal cord).4. This distribution suggests that the role of prostaglandins in the central nervous system is not confined to any specific region.
摘要
开展实验以确定已被确认为大脑天然成分的前列腺素是广泛分布于中枢神经系统的特殊区域还是集中在这些区域。
利用溶剂分配、柱色谱、薄层色谱和生物测定技术在犬脑中鉴定出了前列腺素E(1)、E(2)、F(1α)和F(2α)。
这些前列腺素中的每一种都分布在所研究的中枢神经系统的所有区域（皮质、海马体、尾状核、下丘脑、小脑、延髓和脑桥、皮质白质和脊髓）。
这种分布表明前列腺素在中枢神经系统中的作用并不局限于任何特定区域。
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