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相似文献

1
Mutants of yeast sensitive to ultraviolet light.对紫外线敏感的酵母突变体。
J Bacteriol. 1967 Sep;94(3):571-5. doi: 10.1128/jb.94.3.571-575.1967.
2
Sensitivity to methylmethanesulfonate and nitrous acid of ultraviolet light-sensitive mutants in Saccharomyces cerevisiae.酿酒酵母中紫外线敏感突变体对甲磺酸甲酯和亚硝酸的敏感性
Mol Gen Genet. 1968;102(3):247-56. doi: 10.1007/BF00385981.
3
New type of ultraviolet light-sensitive mutation in yeast.酵母中的新型紫外线敏感突变
J Bacteriol. 1972 Jun;110(3):1206-7. doi: 10.1128/jb.110.3.1206-1207.1972.
4
Common steps in the repair of alkylation and radiation damage in yeast.酵母中烷基化和辐射损伤修复的常见步骤。
Mol Gen Genet. 1970;106(4):289-95. doi: 10.1007/BF00324046.
5
The response to chemical mutagens of the individual haploid and homoallelic diploid UV-sensitive mutants of the rad 3 locus of Saccharomyces cerevisiae.酿酒酵母rad 3基因座的单个单倍体和同基因二倍体紫外线敏感突变体对化学诱变剂的反应。
Mol Gen Genet. 1973 Aug 10;124(2):135-43. doi: 10.1007/BF00265146.
6
Mutagen specificity in the induction of karyotic versus cytoplasmic respiratory deficient mutants in yeast by nitrous acid and alkylating nitrosamides.亚硝酸和烷基化亚硝酰胺诱导酵母中核型与细胞质呼吸缺陷型突变体时的诱变特异性。
Mol Gen Genet. 1968;102(4):290-300. doi: 10.1007/BF00433720.
7
Induction by physical and chemical agents of mutations for radioresistance in Saccharomyces cerevisiae.通过物理和化学因子诱导酿酒酵母产生抗辐射突变
Mutat Res. 1965 Oct;2(5):403-12. doi: 10.1016/0027-5107(65)90052-7.
8
The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast.酵母中紫外线敏感突变体的分离、遗传学及存活特性
Mutat Res. 1968 Jul-Aug;6(1):37-55. doi: 10.1016/0027-5107(68)90101-2.
9
Similarities between a UV-sensitive mutant of yeast and bacterial mutants lacking excision-repair ability.酵母的紫外线敏感突变体与缺乏切除修复能力的细菌突变体之间的相似性。
Mol Gen Genet. 1969 Jul 3;104(3):253-7. doi: 10.1007/BF02539289.
10
Inactivation and the induction of lethal sectoring by chemical mutagens in yeast.酵母中化学诱变剂导致的失活及致死性扇形化诱导
Can J Genet Cytol. 1970 Mar;12(1):10-4. doi: 10.1139/g70-002.

引用本文的文献

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Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability.Rad5 失调导致复制叉处的过度活跃重组，导致顺铂敏感性和基因组不稳定性。
Nucleic Acids Res. 2019 Sep 26;47(17):9144-9159. doi: 10.1093/nar/gkz631.
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Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.Snf2/Swi2家族Rad54运动蛋白在同源重组中的功能。
Biochim Biophys Acta. 2011 Sep;1809(9):509-23. doi: 10.1016/j.bbagrm.2011.06.006. Epub 2011 Jun 16.
4
The accumulation of genetic variability in yeast.酵母中遗传变异性的积累。
Genetics. 1971 Aug;68(4):547-57. doi: 10.1093/genetics/68.4.547.
5
Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation.分析酿酒酵母对甲磺酸甲酯和电离辐射的全局转录反应的剂量依赖性。
BMC Genomics. 2006 Dec 1;7:305. doi: 10.1186/1471-2164-7-305.
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Rad54: the Swiss Army knife of homologous recombination?Rad54：同源重组的瑞士军刀？
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Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations.酿酒酵母中复制后修复的特征以及rad6、rad18、rev3和rad52基因突变的影响。
Mol Gen Genet. 1981;184(3):471-8. doi: 10.1007/BF00352525.
8
Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of Saccharomyces cerevisiae.酿酒酵母切除缺陷型突变体中嘧啶二聚体去除的切割及切割后步骤。
J Bacteriol. 1981 Nov;148(2):618-23. doi: 10.1128/jb.148.2.618-623.1981.
9
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: excision of dimers in cell extracts.酿酒酵母中嘧啶二聚体切除的分子机制：细胞提取物中二聚体的切除
J Bacteriol. 1981 Aug;147(2):705-8. doi: 10.1128/jb.147.2.705-708.1981.
10
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo.酿酒酵母中嘧啶二聚体切除的分子机制：体内紫外线照射的脱氧核糖核酸的切割
J Bacteriol. 1981 May;146(2):692-704. doi: 10.1128/jb.146.2.692-704.1981.

本文引用的文献

1
Chromosome Mapping in Saccharomyces: Centromere-Linked Genes.酿酒酵母中的染色体图谱：着丝粒连锁基因。
Genetics. 1960 Aug;45(8):1085-110. doi: 10.1093/genetics/45.8.1085.
2
Use of snail digestive juice in isolation of yeast spore tetrads.蜗牛消化液在酵母孢子四分体分离中的应用。
J Bacteriol. 1959 Aug;78(2):292. doi: 10.1128/jb.78.2.292-292.1959.
3
ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12.大肠杆菌K12重组缺陷突变体的分离与鉴定
Proc Natl Acad Sci U S A. 1965 Feb;53(2):451-9. doi: 10.1073/pnas.53.2.451.
4
EVIDENCE FOR REPAIR-REPLICATION OF ULTRAVIOLET DAMAGED DNA IN BACTERIA.细菌中紫外线损伤DNA修复复制的证据
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5
RELEASE OF ULTRAVIOLET LIGHT-INDUCED THYMINE DIMERS FROM DNA IN E. COLI K-12.大肠杆菌K-12中DNA上紫外线诱导胸腺嘧啶二聚体的释放
Proc Natl Acad Sci U S A. 1964 Feb;51(2):293-300. doi: 10.1073/pnas.51.2.293.
6
THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.胸腺嘧啶二聚体从DNA中的消失：一种纠错机制。
Proc Natl Acad Sci U S A. 1964 Feb;51(2):226-31. doi: 10.1073/pnas.51.2.226.
7
"Reversible" DNA.“可逆的”DNA
Proc Natl Acad Sci U S A. 1961 Jul 15;47(7):950-5. doi: 10.1073/pnas.47.7.950.
8
Gene-controlled UV-sensitivity in Schizosaccharomyces pombe.粟酒裂殖酵母中基因控制的紫外线敏感性
Mutat Res. 1967 Mar-Apr;4(2):219-21. doi: 10.1016/0027-5107(67)90075-9.
9
Radiation sensitive mutants of Ustilago maydis.玉米黑粉菌的辐射敏感突变体。
Mutat Res. 1965 Dec;2(6):557-9. doi: 10.1016/0027-5107(65)90022-9.
10
Two types of radiation-sensitive mutant in yeast.酵母中的两种辐射敏感突变体。
Mutat Res. 1967 Mar-Apr;4(2):129-36. doi: 10.1016/0027-5107(67)90064-4.

对紫外线敏感的酵母突变体。

Mutants of yeast sensitive to ultraviolet light.

作者信息

Snow R

出版信息

J Bacteriol. 1967 Sep;94(3):571-5. doi: 10.1128/jb.94.3.571-575.1967.

DOI:10.1128/jb.94.3.571-575.1967
PMID:6035260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251924/
Abstract

Six uvr mutants of Saccharomyces cerevisiae with hypersensitivity to ultraviolet (UV) light were isolated after mutagen treatment with ethylmethanesulfonate. UV sensitivity ranges from moderate to extreme, and four of the mutants are also sensitive to nitrous acid. Ranking in terms of UV sensitivity does not parallel ranking in terms of nitrous acid sensitivity. Homozygous diploid mutant strains are somewhat less sensitive than the corresponding haploids. All mutations are recessive. None of the mutants is sensitive to gamma rays, and each shows photoreactivation after UV radiation. Complementation tests and tetrad analysis indicate that each strain represents mutation in a different gene. Two of the uvr genes are linked, and two others are centromere-linked.

摘要

在用甲磺酸乙酯进行诱变处理后，分离出了六株对紫外线（UV）敏感的酿酒酵母uvr突变体。UV敏感性范围从中度到极度，其中四个突变体对亚硝酸也敏感。按UV敏感性排序与按亚硝酸敏感性排序并不平行。纯合二倍体突变菌株比相应的单倍体菌株敏感性略低。所有突变均为隐性。没有一个突变体对γ射线敏感，并且每个突变体在UV辐射后都表现出光复活现象。互补试验和四分体分析表明，每个菌株代表一个不同基因的突变。其中两个uvr基因是连锁的，另外两个与着丝粒连锁。