哈尔满和去甲哈尔满对苯并[a]芘代谢产物体外致突变性及与DNA结合的影响以及对细胞培养中芳烃羟化酶诱导作用的影响。 - Suppr

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超能文献

Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture.

作者信息

Levitt R C, Legraverend C, Nebert D W, Pelkonen O

出版信息

Biochem Biophys Res Commun. 1977 Dec 21;79(4):1167-75. doi: 10.1016/0006-291x(77)91129-9.

DOI:10.1016/0006-291x(77)91129-9

PMID:603652

Abstract

摘要

相似文献

Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture.哈尔满和去甲哈尔满对苯并[a]芘代谢产物体外致突变性及与DNA结合的影响以及对细胞培养中芳烃羟化酶诱导作用的影响。

Biochem Biophys Res Commun. 1977 Dec 21;79(4):1167-75. doi: 10.1016/0006-291x(77)91129-9.

Test-condition-dependent influence of harman and nonharman on benzo[a]pyrene mutagenesis in Salmonella.

Mutat Res. 1982 Apr;104(1-3):9-15. doi: 10.1016/0165-7992(82)90113-0.

The effect of norharman on the metabolism of benzo[alpha]pyrene by rat-liver microsomes in vitro in relation to its enhancement of the mutagenicity of benzo[alpha]pyrene.去甲哈尔满对大鼠肝脏微粒体体外代谢苯并[a]芘的影响及其对苯并[a]芘致突变性的增强作用。

Mutat Res. 1978 Nov;58(2-3):151-8. doi: 10.1016/0165-1218(78)90004-6.

Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.通过选择性诱导微粒体和细胞核芳烃羟化酶活性对致癌物苯并(a)芘在体内与大鼠肝脏DNA结合的调节作用。

Cancer Res. 1978 Dec;38(12):4640-4.

The effects of harman and norharman on the metabolism of benzo(a)pyrene in isolated perfused rat lung and in rat lung microsomes.哈尔满和去氢哈尔满对离体灌注大鼠肺及大鼠肺微粒体中苯并(a)芘代谢的影响。

Biochem Pharmacol. 1979 May 15;28(10):1591-6. doi: 10.1016/0006-2952(79)90170-9.

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by aryl hydrocarbon hydroxylase inducers.芳烃羟化酶诱导剂对体内苯并(a)芘代谢产物与DNA之间加合物形成的抑制作用。

Cancer Res. 1981 Sep;41(9 Pt 1):3453-60.

Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity.

Biochem Pharmacol. 1978;27(8):1203-9. doi: 10.1016/0006-2952(78)90453-7.

Relationship of aryl hydrocarbon hydroxylase activity to benzo(a)pyrene-metabolizing activity of cells in culture.培养细胞中芳烃羟化酶活性与苯并(a)芘代谢活性的关系。

Cancer Lett. 1977 Sep;3(3-4):189-95. doi: 10.1016/s0304-3835(77)95553-7.

Induction of aryl hydrocarbon hydroxylase in primary cultures of type II alveolar lung cells and binding of metabolically activated benzo[a]pyrene to nuclear macromolecules.II型肺泡肺细胞原代培养中芳烃羟化酶的诱导及代谢活化的苯并[a]芘与核大分子的结合。

Cancer Lett. 1979 Oct;7(6):349-55. doi: 10.1016/s0304-3835(79)80065-8.

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.去甲哈尔满和哈尔满与2-乙酰氨基芴衍生物的共诱变效应。

Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. doi: 10.1073/pnas.75.2.928.

引用本文的文献

There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.几种3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的DNA亲和力与致突变性之间存在关联。

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1427-31. doi: 10.1073/pnas.77.3.1427.

Effects of harman and norharman on the metabolism and genotoxicity of 2-acetylaminofluorene in cultured rat hepatocytes.哈尔满和去甲哈尔满对培养的大鼠肝细胞中2-乙酰氨基芴代谢及遗传毒性的影响。

Cell Biol Toxicol. 1985 Jun;1(3):223-39. doi: 10.1007/BF00120166.

Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.哈尔满和去甲哈尔满对N-乙基-N-羟乙基亚硝胺引发的大鼠肾前体病变和肿瘤性病变诱导的增强作用。

Jpn J Cancer Res. 1992 Sep;83(9):949-54. doi: 10.1111/j.1349-7006.1992.tb02006.x.

Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450.氨基酸和蛋白质的热解产物：最高致突变性需要细胞色素P1 - 450。

Proc Natl Acad Sci U S A. 1979 Nov;76(11):5929-33. doi: 10.1073/pnas.76.11.5929.

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