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人类迟发型超敏反应：体外相关性及RNA提取物的传递

Delayed hypersensitivity in man: a correlate in vitro and transfer by an RNA extract.

作者信息

Thor D E

出版信息

Science. 1967 Sep 29;157(3796):1567-9. doi: 10.1126/science.157.3796.1567.

DOI:10.1126/science.157.3796.1567
PMID:6038169
Abstract

The migration of sensitized human monocytic-phagocytic cells from lymph-node tissue-culture suspensions was regularly and specifically inhibited by purified protein derivative or histoplasmin. Moreover, when nonsensitive cells were incubated with an RNA extract from lymph nodes of donors sensitive to purified protein derivative, histoplasmin, or both, the migration of these cells was specifically inhibited by these antigens. Ribonuclease inactivated the RNA extract.

摘要

纯化蛋白衍生物或组织胞浆菌素可正常且特异性地抑制致敏人单核吞噬细胞从淋巴结组织培养悬液中的迁移。此外，当非敏感细胞与来自对纯化蛋白衍生物、组织胞浆菌素或两者敏感的供体淋巴结的RNA提取物一起孵育时，这些细胞的迁移会被这些抗原特异性抑制。核糖核酸酶可使RNA提取物失活。

相似文献

1
Delayed hypersensitivity in man: a correlate in vitro and transfer by an RNA extract.人类迟发型超敏反应：体外相关性及RNA提取物的传递
Science. 1967 Sep 29;157(3796):1567-9. doi: 10.1126/science.157.3796.1567.
2
A correlate of human delayed hypersensitivity: specific inhibition of capillary tube migration of sensitized human lymph node cells by tuberculin and histoplasmin.人类迟发型超敏反应的一个相关因素：结核菌素和组织胞浆菌素对致敏人类淋巴结细胞毛细血管管迁移的特异性抑制。
J Immunol. 1968 Jul;101(1):51-61.
3
The cell-migration-inhibition correlate of delayed hypersensitivity. Conversion of human nonsensitive lymph node cells to sensitive cells with an RNA extract.迟发型超敏反应的细胞迁移抑制关联。用RNA提取物将人非敏感淋巴结细胞转化为敏感细胞。
J Immunol. 1968 Sep;101(3):469-80.
4
In vitro studies with "transfer factor": transfer of the cell-migration inhibition correlate of delayed hypersensitivity in humans with cell lysates from humans sensitized to histoplasmin, coccidioidin, or PPD.“转移因子”的体外研究：将对组织胞浆菌素、球孢子菌素或结核菌素纯蛋白衍生物致敏的人的细胞裂解物与人的迟发型超敏反应的细胞迁移抑制相关因子进行转移。
J Immunol. 1969 Nov;103(5):1014-21.
5
Cultures of human tissues for studies on delayed allergy with observations on sarcoidosis.用于迟发性过敏研究的人体组织培养及结节病观察
J Lab Clin Med. 1970 Mar;75(3):488-98.
6
Interspecies "transfer" of delayed hypersensitivity in vitro with RNA extracts.利用RNA提取物在体外进行种间迟发型超敏反应的“转移” 。
J Immunol. 1970 Dec;105(6):1334-8.
7
Indirect migration inhibition test in xenogeneic systems. I. Delayed hypersensitivity to BCG.异种系统中的间接迁移抑制试验。I. 对卡介苗的迟发型超敏反应。
Bull Acad Pol Sci Biol. 1969;17(10):589-93.
8
In vitro antigenic stimulation of peripheral blood and lymph node lymphocytes of sensitized guinea-pigs; the effect of a second administration of antigen in vivo.致敏豚鼠外周血和淋巴结淋巴细胞的体外抗原刺激；体内再次给予抗原的影响。
Immunology. 1969 Oct;17(4):571-8.
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Human delayed hypersensitivity: an in vitro correlate and transfer by an RNA extract.人类迟发型超敏反应：一种RNA提取物的体外关联及转移
Fed Proc. 1968 Jan-Feb;27(1):16-20.
10
Specific stimulation of mycobacteria phagocytosis by substances liberated during the cultivation of lymph node cells from tuberculin hypersensitive rabbits with the specific antigen.
Experientia. 1972 Apr 15;28(4):467-70. doi: 10.1007/BF02008346.

引用本文的文献

1
Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease.溃疡性结肠炎和克罗恩病中细胞对肠黏膜成分的超敏反应。
Gut. 1969 Aug;10(8):631-6. doi: 10.1136/gut.10.8.631.
2
Demonstration of the inflammatory activity of the supernatant of hypersensitive lymph node cells incubated with a high dose of antigen.高剂量抗原孵育的超敏淋巴结细胞上清液炎症活性的证明。
Immunology. 1969 May;16(5):677-84.
3
Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism.
迟发型超敏反应中可溶性抗原和淋巴细胞介导的细胞毒性。3. 机制分析。
J Exp Med. 1968 Dec 1;128(6):1267-79. doi: 10.1084/jem.128.6.1267.
4
[In vitro study of the pathogenesis of primary chronic polyarthritis by means of migration inhibition test].[通过迁移抑制试验对原发性慢性多关节炎发病机制的体外研究]
Klin Wochenschr. 1970 Nov 1;48(21):1308-11. doi: 10.1007/BF01485523.
5
In vitro demonstration of microbial cellular hypersensitivity in man.人体微生物细胞超敏反应的体外证明。
Proc R Soc Med. 1970 Sep;63(9):903-5. doi: 10.1177/003591577006300918.
6
Preparation and standardization of antigens of Histoplasma capsulatum and Coccidioides immitis.荚膜组织胞浆菌和粗球孢子菌抗原的制备与标准化
Mycopathol Mycol Appl. 1970;41(1):139-53. doi: 10.1007/BF02051490.
7
Transfer factor and other mediators of cellular immunity.转移因子及其他细胞免疫介质。
Am J Pathol. 1970 Sep;60(3):437-52.
8
Cell-mediated immunological processes in leprosy.麻风病中的细胞介导免疫过程。
Bull World Health Organ. 1969;41(6):779-92. doi: 10.5935/0305-7518.19700030.
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Anti-adrenal cellular hypersensitivity in Addison's disease. II. Correlation with clinical and serological findings.艾迪生病中的抗肾上腺细胞超敏反应。II. 与临床及血清学检查结果的相关性。
Clin Exp Immunol. 1969 Oct;5(4):341-53.
10
Bone marrow as source of cells in reactions of cellular hypersensitivity. II. Identification of allogeneic or hybrid cells by immunofluorescence in passively transferred tuberculin reactions.骨髓作为细胞超敏反应中细胞的来源。II. 被动转移结核菌素反应中通过免疫荧光鉴定同种异体或杂交细胞。
J Exp Med. 1968 Dec 1;128(6):1437-47. doi: 10.1084/jem.128.6.1437.