Gilboa N, Durante D, McIntosh R M
J Rheumatol. 1977 Winter;4(4):358-68.
Fifty-three renal specimens from 48 patients with SLE were examined for the presence of RTE in the glomeruli. Glomerular RTE, presumably in immune complex form was detected in 60% of the tissues. The deposition of these complexes was related to the severity of histologic changes and activity of SLE. In addition, glomerular localization of RTE was associated with decreased renal function and increased proteinuria. The association between the presence of glomerular RTE antigen, the severity of renal histologic changes and the decreased renal function suggested a possible role for this antigen in the pathogenesis of lupus nephritis.
对48例系统性红斑狼疮（SLE）患者的53份肾标本进行检查，以确定肾小球中是否存在肾小管上皮细胞（RTE）。在60%的组织中检测到可能以免疫复合物形式存在的肾小球RTE。这些复合物的沉积与组织学改变的严重程度和SLE的活动度相关。此外，RTE的肾小球定位与肾功能下降和蛋白尿增加有关。肾小球RTE抗原的存在、肾组织学改变的严重程度与肾功能下降之间的关联表明，该抗原可能在狼疮性肾炎的发病机制中起作用。
