Reid W M, Dick J, Rice J, Stino F
Poult Sci. 1977 Jan;56(1):66-71. doi: 10.3382/ps.0560066.
Feed medication with monensin caused delays in development of immunity in two floor-pen experiments which simulated commercial broiler production. Development of immunity was retarded with the higher level of monensin (120 p.p.m.) but was progressively less delayed as the monensin level was decreased (100, 60 or 0 p.p.m.). Delay was greatest with Eimeria tenella, but also occured with intestinal species including E. acervulina, E. brunetti, E. maxima, E. mivati, and E. necatrix. Drug withdrawal permitted earlier development of immunity. Plans involving use of monensin on layer replacements which later will be maintained on the floor without medication should consider: 1) prevalence of infective oocyst exposure in the area, 2) the lowest possible level of drug required for protection, and 3) its use for the shortest possible period of time.
在两项模拟商业肉鸡生产的地面平养实验中，投喂含莫能菌素的药物导致免疫发育延迟。莫能菌素水平较高（120 ppm）时免疫发育受到抑制，但随着莫能菌素水平降低（100、60或0 ppm），延迟程度逐渐减轻。柔嫩艾美耳球虫导致的延迟最为严重，但包括堆型艾美耳球虫、布氏艾美耳球虫、巨型艾美耳球虫、米氏艾美耳球虫和毒害艾美耳球虫在内的肠道球虫种类也会导致延迟。停药可使免疫发育提前。在涉及对后备蛋鸡使用莫能菌素，而后将其置于地面不再用药饲养的计划中，应考虑：1）该地区感染性卵囊暴露的流行情况；2）保护所需的最低药物水平；3）尽可能短的使用时间。
