Yasuda J, Arai K
Jpn J Med Sci Biol. 1976 Feb;29(1):1-9. doi: 10.7883/yoken1952.29.1.
(1) An antiglobulin factor, non-neutralizable by human gamma-globulin, was demonstrated in sera of two patients with liver disease. (2) By absorption and elution techniques, two fractions were differentiated in a serum: one is reactive to rabbit antibody and the other seems cross-reactive to rabbit and human antibodies. (3) In double immunodiffusion test, the antiglobulin factor formed a precipitation band with heat-aggregated human IgG as did rheumatoid arthritis serum. (4) While the antiglobulin activity to rabbit antibody was demonstrated in both the IgM and IgG fractions, the reactivity to human antibody was localized in the IgM fraction. (5) From its selective reactivity to individual anti-D sera (sensitizers), at least a part of the specificity of the antiglobulin factor must be related to anti-Gm (1), and consequently can be regarded as auto-reactive.
(1) 在两名肝病患者的血清中发现了一种不能被人γ-球蛋白中和的抗球蛋白因子。(2) 通过吸收和洗脱技术，在一份血清中区分出了两个组分：一个与兔抗体反应，另一个似乎与兔抗体和人抗体都有交叉反应。(3) 在双向免疫扩散试验中，抗球蛋白因子与热聚集的人IgG形成沉淀带，类风湿关节炎血清也是如此。(4) 虽然在IgM和IgG组分中都显示出对兔抗体的抗球蛋白活性，但对人抗体的反应性局限于IgM组分。(5) 从其对个别抗-D血清（致敏剂）的选择性反应来看，抗球蛋白因子的至少一部分特异性一定与抗-Gm(1)有关，因此可被视为自身反应性的。
