人类新生儿第一次呼吸时的压力和容积变化。
Pressure and volume changes during the first breath of human neonates.
作者信息
Milner A D, Sauders R A
出版信息
Arch Dis Child. 1977 Dec;52(12):918-24. doi: 10.1136/adc.52.12.918.
Abstract
The pressure and volume changes associated with the first breath were measured in 17 healthy term babies, using oesophageal balloons and a reverse plethysmograph. 5 babies expanded their lungs with less than --20 cmH2O (--2 kPa). The characteristic opening pressure pattern previously described was seen in only one baby, whose initial volume change was an expiratory one. It is concluded that opening pressures greater than 10 cmH2O (0.96 kPa) are rarely seen in term healthy infants.
摘要
使用食管气囊和反向体积描记器，对17名足月健康婴儿进行了与第一次呼吸相关的压力和体积变化测量。5名婴儿在小于-20 cmH2O（-2 kPa）的压力下扩张肺部。之前描述的特征性开放压力模式仅在一名婴儿中出现，其最初的体积变化是呼气性的。得出的结论是，足月健康婴儿很少出现大于10 cmH2O（0.96 kPa）的开放压力。
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本文引用的文献
1
Respiratory studies in newborn infants. III. Development of mechanics of breathing during the first week of life. A longitudinal study.
Acta Paediatr Suppl (Upps). 1962 Jun;135:121-9. doi: 10.1111/j.1651-2227.1962.tb08666.x.
2
3
Ventilation and ventilatory mechanics in the newborn: methods and results in 15 resting infants.新生儿的通气与通气力学：15名安静婴儿的研究方法与结果
J Pediatr. 1960 May;56:612-22. doi: 10.1016/s0022-3476(60)80334-4.
4
Static volume-pressure relations of excised lungs of infants with hyaline membrane disease, newborn and stillborn infants.患有透明膜病的婴儿、新生儿及死产儿离体肺的静态容量-压力关系
J Clin Invest. 1959 Dec;38(12):2168-75. doi: 10.1172/JCI103996.
5
[Aeration of the lung in the newborn infant].[新生儿肺部的通气]
Biol Neonat. 1959 Oct;1:169-210.
6
Volume-pressure relationships of the thorax and lung in the newborn.新生儿胸廓与肺的容积-压力关系
J Appl Physiol. 1959 Nov;14:909-13. doi: 10.1152/jappl.1959.14.6.909.
7
Surface properties in relation to atelectasis and hyaline membrane disease.与肺不张和透明膜病相关的表面特性
AMA J Dis Child. 1959 May;97(5, Part 1):517-23. doi: 10.1001/archpedi.1959.02070010519001.
8
The inflationary force produced by pulmonary vascular distention in excised lungs; the possible relation of this force to that needed to inflate the lungs at birth.离体肺中肺血管扩张产生的膨胀力；该力与出生时肺膨胀所需力的可能关系。
J Clin Invest. 1959 Mar;38(3):456-62. doi: 10.1172/JCI103821.
9
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