羟基脲对正常人骨髓中粒系干细胞（CFUc）的体外自杀技术描述。
Description of a suicide technique in vitro for granulocytic stem cells (CFUc) by hydroxyurea on normal human bone marrow.
作者信息
Morardet N, Parmentier C
出版信息
Biomedicine. 1977 Dec;27(9-10):349-53.
PMID:606311
Abstract
It has been possible, by studying 15 normal human bone marrow samples, to develop a technique for the suicide effect in vitro by hydroxyurea (H.U.), applied to human granulocytic stem cells (CFUc). This study suggests a contact time of medullary cells from 60 to 80 minutes in the presence of a hydroxyurea concentration 6 mM per 10(6) cells per ml in vitro. Preliminary results concerning the clusters are discussed.
摘要
通过研究15份正常人类骨髓样本，已开发出一种利用羟基脲（H.U.）对人粒细胞干细胞（CFUc）产生体外自杀效应的技术。该研究表明，体外每10(6)个细胞每毫升羟基脲浓度为6 mM时，骨髓细胞的接触时间为60至80分钟。讨论了关于集落的初步结果。
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