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慢性肺部疾病患儿对A/维多利亚/75-A/新泽西/76二价流感疫苗接种的反应性及抗体应答

Reactivity and antibody response to vaccination with bivalent influenza A/Victoria/75-A/New Jersey/76 vaccines in children with chronic pulmonary diseases.

作者信息

Hilman B C, Jamison R M, Kirkpatrick C J

出版信息

J Infect Dis. 1977 Dec;136 Suppl:S638-44. doi: 10.1093/infdis/136.supplement_3.s638.

DOI:10.1093/infdis/136.supplement_3.s638
PMID:606786
Abstract

Reactogenicity and antibody responses of high-risk children and adolescents (aged three to 18 years) to bivalent influenza A/Victoria/75-A/New Jersey/76 virus vaccine from nine participating centers were compared to the response of the total population of vaccinees in the multicenter study of the National Institute of Allergy and Infectious Diseases. Split-product vaccines given in two doses four weeks apart offered protection without a significant risk of side effects. Patients with chronic pulmonary disease did not differ from the total study population to antibody response or reactivity to vaccination with A/New Jersey strains.

摘要

来自九个参与中心的高危儿童和青少年(3至18岁)对二价甲型流感病毒/维多利亚/75-A/新泽西/76病毒疫苗的反应原性和抗体反应,与国立过敏和传染病研究所多中心研究中疫苗接种者的总体反应进行了比较。每隔四周分两剂接种的裂解疫苗可提供保护,且副作用风险不大。慢性肺病患者在抗体反应或对A/新泽西毒株疫苗接种的反应性方面与总体研究人群没有差异。

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