肝脏疾病中的维生素B12和维生素B12结合蛋白

Vitamin B12 and vitamin B12 binding proteins in liver diseases.

作者信息

Areekul S, Panatampon P, Doungbarn J

出版信息

Southeast Asian J Trop Med Public Health. 1977 Sep;8(3):322-8.

Abstract

Serum vitamin B12 and vitamin B12 binding proteins (transcobalamins, TCS) were determined in patients with malaria, amoebic liver abscess, carcinoma of the liver, infectious hepatitis, cirrhosis and chronic myelocytic leukemia (CML) as well as in 60 blood donor subjects. Serum vitamin B12 in patients with infectious hepatitis, cirrhosis and CML were higher than that of the normal subjects. The values of unsaturated vitamin B12 binding capacity (UBBC) in patients with carcinoma of the liver, infectious hepatitis, cirrhosis were lower while that of patients with CML were higher than that of the normal subjects. A markedly increased TCI and decreased TCII was observed in patients with CML while these changes was much less in patients with other liver diseases. The difference was possibly due to a flooding of vitamin B12 from damaged liver cells into the circulation and the decreased synthesis of transcobalamins in patients with liver diseases while the increased granulocytes, the source of TCI, was much increased in patients with CML.

摘要

对疟疾、阿米巴肝脓肿、肝癌、传染性肝炎、肝硬化和慢性粒细胞白血病（CML）患者以及60名献血者进行了血清维生素B12和维生素B12结合蛋白（转钴胺素，TCS）的检测。传染性肝炎、肝硬化和CML患者的血清维生素B12高于正常受试者。肝癌、传染性肝炎、肝硬化患者的不饱和维生素B12结合能力（UBBC）值较低，而CML患者的UBBC值高于正常受试者。CML患者的转钴胺素I（TCI）明显升高，转钴胺素II（TCII）降低，而其他肝病患者的这些变化则小得多。这种差异可能是由于受损肝细胞中的维生素B12大量涌入循环系统，以及肝病患者转钴胺素合成减少，而CML患者中作为TCI来源的粒细胞大量增加所致。