Wolff G, Läuter J
Arch Geschwulstforsch. 1977;47(6):531-40.
Of 257 patients with gastric cancer and of 766 persons with different stages of chronic gastritis or normal gastric mucosa, 35 items from epidemiologic studies were used for this analysis. The comparison of epidemiology of chronic gastritis with epidemiology of stomach cancer by univariate and multivariate variance analysis shows numerous common variables (social group; digestive diseases). Furthermore gastric cancer is characterized by variables which give hints to cancerogenous noxes. Gastric cancer patients are distinguished from persons with atrophic gastritis by the following variables: cancerogenes; social class; genetic factors, and digestive diseases. It is suggested that these factors are relevant for stomach cancerogenesis in atrophic gastritis.
在257例胃癌患者以及766例处于不同阶段的慢性胃炎或胃黏膜正常的人群中,选取了流行病学研究中的35项指标进行该分析。通过单因素和多因素方差分析对慢性胃炎的流行病学与胃癌的流行病学进行比较,结果显示存在众多共同变量(社会群体;消化系统疾病)。此外,胃癌具有一些提示致癌因素的变量特征。胃癌患者与萎缩性胃炎患者在以下变量方面存在差异:致癌因素;社会阶层;遗传因素以及消化系统疾病。研究表明,这些因素与萎缩性胃炎中的胃癌发生相关。