Wolff G, Läuter J
Arch Geschwulstforsch. 1976;46(1):1-14.
257 stomach cancer patients and 766 controls were interviewed using a standardized questionnaire for 35 variables. The two groups were compared by multivariate variance analysis. This analysis results in a combination of 20 variables significantly connected with gastric cancer. The rankorder of the most prominent variables is as follows: no food intolerance, higher alcohol consumption, living place near Berlin, occupation labourer, early loss of teeth, car driving, no gallstones, smoking and age. It can be assumed that these variables are of aetiological importance. In the aetiology of gastric cancer, exogenous cancerogens seem to play a more important role than endogenous factors. In two further multivariate variance analysis, control group is divided into persons with and persons without chronic gastritis verified by blind gastric biopsy and compared with gastric cancer patients, too. A fourth analysis is limited to female only. The results of the three last mentioned analysis are similar to those of the first one and also similar to results from other countries based on univariate analysis. The computed combination of variables was used for diagnosis of gastric cancer by discriminance analysis in the persons forming the material for this study. This diagnosis was correct in 71% of gastric cancer patients and in 72% of control persons.
使用标准化问卷对257名胃癌患者和766名对照者进行了35个变量的访谈。通过多变量方差分析对两组进行比较。该分析得出20个与胃癌显著相关的变量组合。最突出变量的排序如下:无食物不耐受、饮酒量较高、居住在柏林附近、职业为体力劳动者、牙齿过早脱落、开车、无胆结石、吸烟和年龄。可以认为这些变量具有病因学重要性。在胃癌病因学中,外源性致癌物似乎比内源性因素发挥更重要的作用。在另外两项多变量方差分析中,将对照组分为经盲法胃活检证实有慢性胃炎和无慢性胃炎的人群,并也与胃癌患者进行比较。第四项分析仅限于女性。最后提到的三项分析结果与第一项分析结果相似,也与其他国家基于单变量分析的结果相似。通过判别分析,将计算出的变量组合用于本研究材料中人群的胃癌诊断。该诊断在71%的胃癌患者和72%的对照者中是正确的。