Ogata K, Whiteside L A, Lesker P A, Simmons D J
Clin Orthop Relat Res. 1977 Nov-Dec(129):313-8. doi: 10.1097/00003086-197711000-00044.
Unicompartmental osteoarthritis was produced by applying varus stress to moving rabbit knee joints. Degenerative changes were confined to the medial tibial and the medial femoral articular surfaces. Within the range of varus stress used, duration appears to be more important than magnitude of varus stress in determining the severity of cartilage damage. The calcified zone remained histologically unchanged despite advanced changes in the noncalcified zone superficial to the tidemark. Intrachondral degenerative cysts were frequently found in the basilar layers of the noncalcified cartilage adjacent to the tidemark where shear stresses were likely to be highest and diffusible nutrients least available. Highly cellular cartilaginous tissue was noted in the subchondral marrow spaces in the specimens with advanced cartilage degeneration. These areas appeared to be continuous with the overlying degenerated cartilage through gaps in the calcified cartilage. Subchondral bone did not show remarkable trabecular thickening despite advanced degenerative changes in the articular cartilage.
通过对活动的兔膝关节施加内翻应力来诱发单髁骨关节炎。退变改变局限于胫骨内侧和股骨内侧关节面。在所使用的内翻应力范围内，在决定软骨损伤的严重程度方面，持续时间似乎比内翻应力的大小更为重要。尽管潮标上方的非钙化区有进展性改变，但钙化区在组织学上保持不变。在靠近潮标的非钙化软骨基底层经常发现软骨内退变囊肿，此处剪切应力可能最高而可扩散营养物质最少。在软骨退变进展的标本中，在软骨下骨髓间隙可见高度细胞化的软骨组织。这些区域似乎通过钙化软骨中的间隙与上方退变的软骨相连。尽管关节软骨有进展性退变改变，但软骨下骨并未显示明显的小梁增厚。
