Takai Y, Murase N, Hosaka M, Kawamura K, Mori M
Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;47(2):183-7. doi: 10.1007/BF02890201.
The immunohistochemical distribution of keratin is reported in experimental carcinogenesis in the mouse submandibular gland (SMG). The initial changes included degranulation of granular convoluted tubule (GCT) cells and the appearance of keratin in the degranulated cells. There was a gradual increase in the area showing keratin staining in the altered tubule cells. Duct-like and cystic structures exhibited an intense keratin staining of their lining epithelium. The squamous cell carcinomas induced varying degrees of keratinization and positive immunohistochemical keratin staining. The latter technique provided a useful marker for distinguishing tumor cells of segmental duct origin in the salivary gland.
本文报道了角蛋白在小鼠下颌下腺（SMG）实验性致癌过程中的免疫组织化学分布情况。最初的变化包括颗粒曲管（GCT）细胞脱颗粒以及脱颗粒细胞中出现角蛋白。在发生改变的小管细胞中，显示角蛋白染色的区域逐渐增加。导管样和囊性结构的内衬上皮呈现强烈的角蛋白染色。鳞状细胞癌呈现出不同程度的角化以及免疫组织化学角蛋白染色阳性。后一种技术为区分唾液腺中节段性导管起源的肿瘤细胞提供了一种有用的标记物。
