Metz O, Thränhardt H, Zwacka G, Plenert W
Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(5):581-8.
K (killer) and natural killer (NK) cells were investigated in peripheral blood of 76 children, preterm small for date babies (n = 8), preterm babies (n = 15), fullterm small for date babies (n = 6) fullterm babies (n = 7) and infants up to 12 months age (n = 40). The K and NK cell activity of human leukocytes was analysed as compared with those cells of the K 562 cell line and murine cells covered by xenologous antibodies in Graffi erythroblast leukemia by means of the 51Cr release test. K cell activities were significantly lower in preterm small for date babies to infants with 1-12 months of age. In our results it is shown that NK capacity of preterm or term newborns and infants up to 6 months age does not differ significantly from each other. Children who are 6-12 months old will have significantly higher NK cell activities. It can be concluded that K cell activities are fully developed during pregnancy and NK cell activities later when the children are between 6 and 12 months of age.
对76名儿童的外周血中的杀伤（K）细胞和自然杀伤（NK）细胞进行了研究，这些儿童包括足月小样儿（n = 8）、早产儿（n = 15）、足月小样儿（n = 6）、足月儿（n = 7）以及12个月龄以下的婴儿（n = 40）。通过51Cr释放试验，分析了人类白细胞的K细胞和NK细胞活性，并与K562细胞系的细胞以及在格拉夫成红细胞白血病中被异种抗体覆盖的鼠细胞进行了比较。足月小样儿至1 - 12个月龄婴儿的K细胞活性显著较低。我们的结果表明，早产或足月新生儿以及6个月龄以下婴儿的NK能力彼此之间没有显著差异。6 - 12个月大的儿童NK细胞活性会显著更高。可以得出结论，K细胞活性在孕期完全发育，而NK细胞活性在儿童6至12个月大时发育。
