人类新生儿淋巴细胞的自然杀伤细胞功能。
Natural killer cell function of human neonatal lymphocytes.
作者信息
Uksila J, Lassila O, Hirvonen T
出版信息
Clin Exp Immunol. 1982 Jun;48(3):649-54.
Abstract
Human natural killer cell (NK cell) activity against K-562 target cell line was evaluated in full term cord blood (n = 30) and adult peripheral blood (n = 20) using 51Cr release assay. The level of NK cell activity was lower in cord blood compared to adult controls (39.6 +/- 11.4% vs 27.4 +/- 11.8% at effector:target ratio 50:1). Adult males showed a significantly higher NK activity compared to females. No sex difference was observed in cord blood. Furthermore, partially purified human leucocyte interferon (IFN alpha) increased in vitro NK cell function of both adult and newborn lymphocytes. The present results indicate that the appearance and maturation of human NK cells occurs during the intrauterine life of the human fetus.
摘要
采用51Cr释放试验，对足月脐带血（n = 30）和成人外周血（n = 20）中人类自然杀伤细胞（NK细胞）针对K-562靶细胞系的活性进行了评估。与成人对照组相比，脐带血中NK细胞活性水平较低（效应细胞：靶细胞比例为50:1时，分别为39.6 +/- 11.4%和27.4 +/- 11.8%）。成年男性的NK活性显著高于女性。脐带血中未观察到性别差异。此外，部分纯化的人白细胞干扰素（IFNα）可增强成人和新生儿淋巴细胞的体外NK细胞功能。目前的结果表明，人类NK细胞的出现和成熟发生在人类胎儿的子宫内生活期间。
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Ann Rheum Dis. 1980 Feb;39(1):82-6. doi: 10.1136/ard.39.1.82.
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