Emerging pathophysiological concepts in hypertension.

Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emerging concerning the interrelationships of these pressor mechanisms and the other factors involved with circulatory control. An inscription on the United States Archives Building reads, "What is past is prologue." It would seem that as we understand more about the fundamental information concerned with the interrelationships of those mechanisms implicated in Page's mosaic, improved therapy will result in further improvements in cardiovascular morbidity and mortality. Indeed, the new knowledge acquired will stimulate further inquiry not only into hypertension but also into other related cardiovascular diseases.